清热化湿调气通络法治疗急性溃疡性结肠炎的临床研究

Clinical Observation on Qingre Huashi Tiaoqi Tongluo Method on Acute Ulcerative Colitis

目的观察清热化湿调气通络法治疗急性溃疡性结肠炎的临床疗效。方法将90例急性溃疡性结肠炎患者按1∶1原则随机分为对照组与治疗组,对照组采用柳氮磺胺吡啶片治疗,治疗组在对照组的基础上采用清热化湿调气通络法治疗。两组均治疗2周。结果两组治疗后腹痛评分、腹泻评分、脓血便评分、里急后重评分、结肠镜评分、Mayo指数评分、黏膜组织评分、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)较治疗前降低(P<0.05),且治疗组低于对照组(P<0.05)。两组治疗后IBDQ评分及白细胞介素-10(IL-10)较治疗前升高(P<0.05),且治疗组高于对照组(P<0.05)。治疗组总有效率高于对照组(P<0.05)。结论清热化湿调气通络法治疗急性溃疡性结肠炎能够改善临床症状,调控炎症因子表达,促进肠黏膜组织修复,提高生活质量及临床疗效。

Objective:To observe the clinical efficacy of Qingre Huashi Tiaoqi Tongluo method on acute ulcerative colitis. Methods:90 patients were randomly divided into the control group and the treatment group,45 cases in each. The control group was treated with Sulfasalazine Tablets. The treatment group was treated with Qingre Huashi Tiaoqi Tongluo method on that basis. Both groups were treated for 2 weeks. Results:After treatment,abdominal pain score,diarrhea score,pus and bloody stool score,urgency score,colonoscopy score,Mayo index score,mucosal tissue score,hs-CRP,IL-6 and TNF-α were lower than before treatment(P < 0.05),and the treatment group was lower than the control group(P < 0.05). IBDQ score and IL-10 level were higher than those before treatment(P < 0.05),and the treatment group was higher than the control group(P < 0.05). The total effective rate of the treatment group was higher than that of the control group(P < 0.05). Conclusion:Qingre Huashi Tiaoqi Tongluo method on acute ulcerative colitis can improve clinical symptoms,regulate the expression of inflammatory factors,promote intestinal mucosal tissue repair,and improve the quality of life and clinical efficacy.