痰热清注射液治疗急性脑卒中伴发卒中相关性肺炎的临床观察

Clinical Observation of Tanreqing Injection on Acute Stroke Associated Pneumonia

目的探讨痰热清注射液治疗急性脑卒中伴发卒中相关性肺炎患者的临床疗效。方法选取急性脑卒中伴发卒中相关性肺炎患者103例,根据随机数字表法分为观察组52例与对照组51例。对照组给予常规治疗,观察组在对照组治疗的基础上加用痰热清注射液治疗,两组治疗时间为7 d。结果发现观察组总有效率明显高于对照组(P<0.05)。两组治疗3 d及7 d,降钙素原(PCT)、C反应蛋白(CRP)水平均明显降低,观察组在治疗7 d时,PCT、CRP水平明显低于对照组(均P<0.05)。两组治疗后肺部感染评分(CPIS)及美国国立卫生研究院卒中量表(NIHSS)均明显降低,且观察组评分降低程度更明显(均P<0.05)。观察组胸部影像恢复时间、住NICU时间、体温恢复正常及白细胞计数恢复正常时间均明显短于对照组(均P<0.05)。结论痰热清注射液治疗急性脑卒中伴发卒中相关性肺炎,能明显降低血清PCT、CRP水平,改善患者NIHSS及CPIS评分,并明显缩短患者胸部影像恢复时间、住NICU时间、体温恢复正常及白细胞计数恢复正常时间。

Objective:To explore the effect of Tanreqing Injection on the stroke associated pneumonia patients.Methods:103 patients were randomly divided into the observation group(52 cases)and the control group(51 cases). The control group was given routine treatment,and the observation group was treated with Tanreqing Injection on that basis. The treatment time was 7 days. Results:The total effective rate of the observation group was significantly higher than that of the control group(P < 0.05). The levels of PCT and CRP in both groups were significantly reduced on the 3rd and 7th day of treatment. The levels of PCT and CRP in the observation group were significantly lower than those in the control group on 7th day of treatment(P < 0.05). After treatment,the scores of CPIS and NIHSS in both groups were significantly lower,and those in the observation group were significantly lower(P <0.05). The recovery time of chest image,the time of living in NICU,the recovery time of temperature and the recovery time of leukocyte count in the observation group were significantly shorter than those in the control group(P < 0.05). Conclusion:Tanreqing Injection can significantly reduce the levels of serum PCT and CRP,decrease the NIHSS and CPIS scores,and significantly shorten the recovery time of chest image,the time of living in NICU,the time of temperature recovery and the time of white blood cell count recovery.