核受体作为炎症性肠疾病治疗靶点的研究进展

Progress in Research on Nuclear Receptors as Therapeutic Targets for Inflammatory Bowel Diseases

炎症性肠疾病是一种慢性肠道炎症疾病,其发病机制尚不明确,目前多认为与炎症和肠黏膜损伤有关。核受体是一种重要的转录调节因子,包括孕烷X受体(pregnane X receptor,PXR)、法尼酯X受体(farnesoid X receptor,FXR)和组成型雄甾烷受体(constitutive androstane receptor,CAR)等。近年深入研究发现,核受体可以通过抑制炎症信号通路、调节肠道紧密连接蛋白及代谢酶的表达减轻肠道炎症,并维持肠黏膜屏障功能,在炎症性肠疾病肠道保护方面发挥重要作用。因此,本文综述核受体PXR、FXR和CAR对炎症性肠疾病肠道的保护作用机制,为以核受体为靶点的炎症性肠疾病药物治疗提供新思路。

Inflammatory bowel disease(IBD) is a chronic intestinal inflammatory disease whose pathogenesis is still unclear. It is currently believed to be associated with inflammation and intestinal mucosal damage. Nuclear receptors are important transcriptional regulators, including pregnane X receptor(PXR), farnesoid X receptor(FXR), and constitutive androstane receptors(CAR), etc. In recent years, it has been found that nuclear receptors can play an important role in intestinal protection of IBD by inhibiting inflammatory signaling pathways, regulating intestinal tight junction proteins and metabolic enzyme expression to alleviate intestinal inflammation and maintain intestinal mucosal barrier function. Therefore, This article reviews the protective effects of nuclear receptors PXR, FXR and CAR on the intestinal tract of IBD, which might provide new ideas for the treatment of IBD based on nuclear receptors targets.