小檗碱的药理作用及机制的研究现状

Research Progress on Pharmacological Effect and Mechanism Action of Berberine

小檗碱亦称黄连素,是从中药黄连中分离的一种季铵生物碱,是中药黄连的主要成分。现代药理研究表明,小檗碱具有抗菌、抗氧化、消炎、降血糖、降脂、抗凋亡等多种生物活性。近年来随着研究的不断进展,作为一种多靶点治疗的药物,小檗碱对动脉粥样硬化、心血管疾病、糖尿病等均具有良好效果。鉴于其诸多的优点,其具有良好的应用前景。本研究就小檗碱药理作用及机制等研究进展作一简要综述,为其应用于临床治疗疾病提供进一步科学依据。

Berberine, also known as berberinum, is a quaternary ammonium alkaloid isolated from the Coptidis Rhizoma and it is the main component of the coptischinensis. Modern pharmacological studies have shown that berberine has a variety of biological activities such as anti-bacterial, anti-oxidative stress, anti-inflammatory, hypoglycemic, hypolipidemic and anti-apoptosis. The advances in research in recent years of berberine, as a drug of multi-target treatment, has been evidenced to possess numerous pharmacological activies, including atherosclerosis, cardiovascular diseases, diabete, etc. In view of its advantages, it has a promising application prospect. Research progress on the pharmacological effect and mechanism of berberine was briefly reviewed in this paper to provide reference for the clinical treatment of diseases in the future.