新型冠状病毒基因组学研究进展

Advances in Genomics Research of Novel Coronavirus

目的对新型冠状病毒(SARS-CoV-2)的基因组研究进展进行综述,以期为疫情防控相关研究提供参考。方法结合国内外最新研究报道,从SARS-CoV-2基因组结构和进化机制等方面,对SARS-CoV-2的研究进展进行归纳与整理。结果与结论基于基因组序列的遗传进化分析,病毒基因组现阶段没有发生显著的变异和重组,但在人际传播和感染过程中病毒可能发生一定的适应性进化,这对检测和药物研发可能存在影响。未来需要对覆盖全球的患者病毒分离株和野外动物携带病毒株进行基于全基因组测序和进化分析,监控病毒变异和解析适应性进化机制,这有助于疫情防控。

OBJECTIVE To review the advance in the research of the 2019 Novel Coronavirus(SARS-CoV-2), with a view to providing reference for research related to outbreak prevention and control. METHODS On the basis of the latest domestic and foreign articles, the progress of genomics research of SARS-CoV-2 were summed up. RESULTS & CONCLUSION Evolutionary analysis based on genomic sequences suggested that the virus may evolve adaptively during the process of human-to-human transmission and infection, which may affect the effectiveness of current detection and diagnosis. It is suggested that the whole genome-based evolutionary analysis of large-scale virus isolates and wild animals carrying virus strains should be carried, and the adaptive evolution mechanisms of virus variation should be monitored and analyzed, which can provide research basis for epidemic prevention and control.