血清1,25-二羟维生素D3水平与新生儿呼吸窘迫综合征的关系研究

Relationship between serum 1,25-dihydroxyvitamin D3 level and neonatal respiratory distress syndrome

目的探讨血清1,25-二羟维生素D3水平与新生儿呼吸窘迫综合征(NRDS)的关系。方法选取2016年6月至2019年6月该院新生儿病房收治的100例NRDS患儿,另从在该院产科分娩的健康新生儿中择取33例作为对照组。收集两组的性别、胎龄、出生体质量、Apgar评分、分娩方式、母体有无妊娠期糖尿病、高血压及甲状腺疾病等基本资料,并采用酶联免疫吸附法检测两组血清1,25-二羟维生素D3水平,采用二分类Logistic回归模型筛选NRDS的独立危险因素。结果NRDS组的血清1,25-二羟维生素D3水平明显低于对照组(P<0.05)。NRDS组、对照组的维生素D缺乏发生率差异具有统计学意义(P<0.05)。与对照组相比,NRDS组胎龄、出生体质量、5min Apgar评分明显降低,差异均有统计学意义(P<0.05),但两组的性别比例、剖宫产比例、母体妊娠期糖尿病比例、母体妊娠期高血压比例、母体妊娠期甲状腺疾病比例相比差异无统计学意义(P>0.05)。二分类Logistic回归分析结果显示,胎龄、出生体质量、1,25-二羟维生素D3水平是新生儿发生NRDS的独立危险因素。结论血清1,25-二羟维生素D3缺乏与NRDS的发生风险密切相关。

Objective To investigate the relationship between serum 1,25-dihydroxyvitamin D3 level and neonatal respiratory distress syndrome(NRDS).Methods A total of 100 cases of NRDS in the neonatal ward of this hospital from June 2016 to June 2019,and 33 healthy neonates were included as the control group.The basic data as gender,gestational age,birth weight,Apgar score,mode of delivery,maternal diabetes mellitus,hypertension and thyroid diseases were collected.Levels of serum 1,25-dihydroxyvitamin D3 were detected by ELISA in each group.Independent risk factors of NRDS were screened by two-class Logistic regression model.Results The serum level of 1,25-dihydroxyvitamin D3 in the NRDS group was significantly lower than that in the control group(P<0.05).There were significant differences in the incidence of vitamin D deficiency between the NRDS group and the control group(P<0.05).Compared with the control group,the gestational age,birth weight and 5 min Apgar score of the NRDS group were significantly lower with statistical significance(P<0.05),but there were no significant differences in ratio of gender,cesarean section,maternal gestational diabetes mellitus,maternal pregnancy hypertension and maternal pregnancy thyroid disease between the two groups(P>0.05).Two-class Logistic regression analysis showed that gestational age,birth weight and 1,25-dihydroxyvitamin D3 level were independent risk factors for NRDS.Conclusion Serum1,25-dihydroxyvitamin D3 deficiency is closely related to the risk of NRDS in neonates.