液体活检在非小细胞肺癌靶向治疗中应用

Application of liquid biopsy in targeted treatment of non-small cell lung cancer

目的液体活检技术在肿瘤的检测方法中是尤为重要的检测手段。其在指导非小细胞肺癌(non-small cell lung cancer,NSCLC)靶向药物的选择、耐药监测以及预后评估等方面具有重要作用,本研究分析近年来国内外液体活检在NSCLC靶向治疗中的应用,以期明确液体活检对NSCLC靶向治疗的指导作用,进而有助于指导靶向药物在NSCLC治疗中的应用。方法应用PubMed、中国知网及中国期刊全文数据库检索系统,以"液体活检、循环肿瘤DNA、循环肿瘤细胞、靶向治疗、非小细胞肺癌"为关键词,检索2009-2019年发表的相关文献。纳入标准:(1)液体活检的机制;(2)靶向治疗在NSCLC中的应用;(3)NSCLC的治疗。排除标准:(1)中文非核心期刊的文献和英文非SCI收录文献;(2)结果重复且相对陈旧的实验研究。根据纳入标准和排除标准,最终29篇文献纳入分析。结果液体活检技术可对NSCLC的诊断、治疗及预后评估进行实时动态监测,及时获取肿瘤基因突变信息,在指导靶向药物选择,对耐药监测以及预后评估等方面具有重要作用。结论液体活检对指导NSCLC患者的靶向治疗具有重要作用,有助于NSCLC患者靶向药物治疗的选择。

OBJECTIVE Liquid biopsy technology is a particularly important means of detection in tumor detection methods.It plays an important role in guiding the selection of non-small cell lung cancer(NSCLC)targeted drugs,drug resistance monitoring and prognosis evaluation,this study reviewed the recent application of liquid biopsy in NSCLC targeted therapy in recent years,in order to clarify the guiding role of liquid biopsy in the targeted therapy of NSCLC,and thus help to improve the application of NSCLC targeted therapy.METHODS Apply PubMed,China Knowledge Network and China Journal Full-text Database Retrieval System,the related literature published in the past 10 years was searched for by"liquid biopsy;circulating tumor DNA;circulating tumor cells;targeted therapy;non-small cell lung cancer".Inclusion criteria:(1)the mechanism of liquid biopsy;(2)the application of targeted therapy in NSCLC;(3)the treatment of NSCLC.Exclusion criteria:(1)Chinese non-core journal literature and English non-SCI literature;(2)Repeated and relatively old experimental results.According to the inclusion criteria and exclusion criteria,29 articles were finally selected for inclusion in the analysis.RESULTS Liquid biopsy technology can dynamically monitor the diagnosis,treatment and prognosis of NSCLC in real time,and obtain information on tumor gene mutation in time,it plays an important role in guiding targeted drug selection,drug resistance monitoring and prognosis evaluation.CONCLUSION Liquid biopsy plays an important role in guiding targeted therapy in patients with NSCLC and helps to improve the treatment of targeted NSCLC patients.