慢性肾脏病患者并发蛋白质-能量消耗的诊治进展

Progress in Diagnosis and Treatment of Protein-energy Wasting in Patients with Chronic Kidney Disease

近年来,虽然慢性肾脏病(chronic kidney disease,CKD)在治疗手段上取得了一定的成果,但蛋白质-能量消耗(protein-energy wasting,PEW)在CKD患者尤其是终末期肾脏病(ESRD)患者中仍然广泛存在。目前PEW发病机制未完全明确,可能与食欲调节中枢抑制、蛋白质分解代谢增强、内分泌功能紊乱、营养物质透析时丢失有关。作为患者身心健康的拦路石,其与患者预后不良密不可分,极大地提升了患者的住院率以及病死率。所以选择合适的干预措施尤为重要,本文就近年来PEW干预措施的研究进展展开综述。

In recent years, although chronic kidney disease(CKD) has made some achievements in the treatment, but protein-energy wasting(PEW) is still widely available for patients with CKD, especially for those with end-stage kidney disease(ESRD). The pathogenesis of PEW is not completely clear, which may be related to inhibition of appetite regulation center, enhancement of protein catabolism, endocrine dysfunction, and loss of nutrients during dialysis. As a roadblock to patients’ physical and mental health, it is closely related to poor prognosis of patients, which greatly influences the rate of hospitalization and mortality of patients.So choosing appropriate interventions is particularly important.This paper reviews the recent progress of PEW interventions.