TP化疗联合三维适形放疗对宫颈癌患者血清PTEN mRNA水平、T淋巴细胞、生存率及复发转移的影响

Effects of TP Chemotherapy Combined with Three-dimensional Conformal Radiotherapy on Serum PTEN mRNA Level,T Lymphocytes,Survival Rate and Recurrence and Metastasis in Patients with Cervical Cancer

目的:探讨TP化疗联合三维适形放疗对宫颈癌患者血清PTEN mRNA水平、T淋巴细胞、生存率及复发转移的影响。方法:选取本院收治的宫颈癌患者100例,按随机数字表法分为研究组(TP化疗联合三维适形放疗)和对照组(单纯三维适形放疗),各50例。检测两组血清PTEN mRNA、T淋巴细胞水平,统计患者的生存率及复发、转移情况。结果:两组治疗后血清PTEN mRNA水平均显著高于治疗前,且研究组显著高于对照组(P<0.05);两组治疗后T淋巴细胞水平显著下降,且研究组均显著高于对照组(P<0.05);研究组1、2、3年生存率均显著高于对照组(P<0.05),研究组复发率、转移率均显著低于对照组(P<0.05)。结论:TP化疗联合三维适形放疗对宫颈癌患者血清PTEN mRNA和T淋巴细胞水平的改善效果较佳,可提升患者的机体免疫力,提高生存率,减少复发转移的发生。

Objective:To investigate the effects of TP chemotherapy combined with three-dimensional conformal radiotherapy on serum PTEN mRNA level,T lymphocytes,survival rate and recurrence and metastasis of cervical cancer patients.Method:A total of 100 patients with cervical cancer were selected,according to the random number table,the patients were divided into the study group(TP chemotherapy combined with 3D conformal radiotherapy)and the control group(only 3D conformal radiotherapy),50 cases in each group.The levels of PTEN mRNA and T lymphocyte in serum of the two groups were measured,and the survival rate,recurrence and metastasis of the patients were counted.Result:The level of PTEN mRNA in the two groups after treatment were significantly higher than those before treatment,and the level of PTEN mRNA in the study group was significantly higher than that in the control group(P<0.05).The level of T lymphocyte in the two groups decreased significantly after treatment,and the level in the study group were significantly higher than those in the control group(P<0.05).The 1,2 and 3 years survival rates of the study group were significantly higher than those of the control group(P<0.05),and the recurrence and metastasis rates of the study group were significantly lower than those of the control group(P<0.05).Conclusion:TP chemotherapy combined with 3D conformal radiotherapy has a better effect on the improvement of serum PTEN mRNA and T lymphocyte levels in patients with cervical cancer,which can improve the patient’s immunity,improve survival rate and reduce the occurrence of recurrence and metastasis.