血清炎症指标水平与良性前列腺增生的相关性研究

Correlative Studies on Serum Inflammatory Indexs and Benign Prostatic Hyperplasia

目的探讨血清炎症指标水平与中老年患者良性前列腺增生(benign prostatic hyperplasia,BPH)的相关性。方法选取2019-04月在中部战区总医院体检中心接受健康体检的军队离退休干部104例为研究对象,依据《中国泌尿外科疾病诊断治疗指南》,将研究对象分为BPH组(n=54)和非前列腺增生(NBPH)组(n=50)。检测两组患者的血压、身高、体质量、体质量指数(body mass index,BMI)、血常规、C-反应蛋白(C-reactive protein,CRP)、总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、空腹血糖(fasting plasma glucose,FPG)、血尿酸(uric acid,UA)、前列腺特异性抗原(prostate specific antigen,PSA)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素6(interleukin-6,IL-6)和IL-8等指标。结果BPH组患者的年龄、BMI、LDL-C、UA、PSA、前列腺体积(prostate volume,PV)水平显著高于NBPH组(P<0.01),BPH组患者TNF-α、IL-6、中性粒细胞与淋巴细胞比值(neutrophil/lymphocyte ratio,NLR)水平明显高于NBPH组(P<0.05)。Pearson相关分析显示PV与TNF-α、IL-6、NLR呈显著相关,与CRP、IL-8无相关;进一步采用多因素逐步回归分析显示,PV与IL-6、NLR呈显著正相关。结论血清炎性指标水平升高可能促进BPH发生发展,检测血清相关炎症指标,对进一步认识前列腺增生发病机制具有临床指导意义。

Objective To investigate the association of serum inflammatory indexs with benign prostatic hyperplasia(BPH)in middle-aged and elderly.Methods A total of 104 retired army cadres with integrated physical examination data in General Hospital of Central Theater Command in April 2019 were enrolled.According to the guidelines for diagnosis and treatment of urological diseases in China,all patients were divided into BPH group(n=54)and none-benign prostate hyperplasia(NBPH)group(n=50).The blood pressure,height,weight,body mass index(BMI),blood routine,C-reactive protein(CRP),total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),fasting plasma glucose(FPG),uric acid(UA),prostate specific antigen(PSA),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and IL-8 of paitents in two groups were collected and analyzed.Results The age,BMI,LDL-C,UA,PSA and prostate volume(PV)in BPH group were significantly higher than those in NBPH group(P<0.01),and the levels of TNF-α,IL-6 and neutrophil/lymphocyte ratio(NLR)in the BPH group were significantly higher than those in NBPH group(P<0.05).Pearson correlation analysis result showed that PV was significantly correlated with TNF-α,IL-6 and NLR,but not with CRP and IL-8.Further multivariate logistic stepwise regression analysis showed that PV was positively correlated with IL-6 and NLR.Conclusion The increase of serum inflammatory indexs may promote the development of BPH.Detection of serum inflammatory indexs are of great clinical significance for further understanding of the pathogenesis of BPH.