血清中CysC、RBP、Hcy、CRP水平与糖尿病肾病分期相关性研究

Correlation between levels of CysC, RBP, Hcy and CRP in serum and stage of diabetic nephropathy

目的探讨血清中胱抑素C(CysC)、视黄醇结合蛋白(RBP)、同型半胱氨酸(Hcy)、C反应蛋白(CRP)水平与糖尿病肾病分期的相关性。方法选取2016年7月至2018年8月阜阳市人民医院468例糖尿病肾病患者作为研究对象,使用简化的MDRD公式计算肾小球滤过率(GFR),根据K/DOQI慢性肾脏病临床实践指南将患者分为Ⅰ~Ⅴ期,利用西门子2400全自动生化仪测定患者血清中CysC、RBP、Hcy、CRP水平,利用Graphpad 5.0统计学软件进行数据处理并作回顾性分析比较。结果对468例糖尿病肾病患者根据血肌酐估算肾小球滤过率并利用其进行肾损伤分期,其中I期233例,II期70例,III期95例,IV期37例,V期33例。随后分别对肾损伤分期与CysC、RBP、Hcy、CRP相关性进行分析,结果显示,糖尿病肾病患者肾损伤程度与四个指标均具有相关性。其中肾损伤程度与CysC相关系数为0.5264(P<0.001);其与RBP和Hcy的相关系数分别为0.3355和0.2877(P<0.001);而肾损伤程度与CRP相关系数为0.0122(P=0.0168)。结论联合检测患者血清中CysC、RBP、Hcy、CRP水平与糖尿病肾病分期均有一定的临床价值,而CysC更能贴切的反应糖尿病肾损伤程度。

Objective To explore the correlation between the four kinds of serum target,CysC,RBP,Hcy and CRP and stage of diabetic nephropathy.Methods The 468 diabetic nephropathy patients were selected for this study from people's hospital of Fuyang during July 2016 to August 2018.The GFR was calculated using simplified formula of MDRD and the patients were grouped five groups(stage I to stage V)according to K/DOQI,the treatment guidelines of chronic kidney.Meanwhile the level of four routine serum targets,CysC,RBP,Hcy and CRP,were detected by automatic biochemical apparatus of Siemens 2400 model.And the datum were analyzed using the software of Graphpad 5.0 retrospectively.Results The level of serum creatinine 468 diabetic nephropathy patients was detected to evaluate the extent of renal injury.There were the five groups containing 233,70,95,37 and 33 patients from stage I to stage V respectively.And then the correlation between targets and renal injury was significant,the statistics results showed the correlation coefficient(r^2)was 0.5264 between renal injury and CysC(P<0.001).The correlation coefficient of RBP,Hcy(r^2)was 0.3355 and 0.2877(P<0.001)respectively.The CRP showed a low correlation with renal injury(r^2=0.0122,P=0.0168).Conclusions This study suggested the level of four serum targets is valueable for evaluation of renal injury and CysC maybe evaluate the degree of renal injury.