摘要
介绍了厄他培南钠中间体3个有关物质的合成方法,并对其进行了HRMS和NMR(1H NMR、COSY、13C NMR、DEPT135°、HSQC、HMBC和D2O)确证以及碳氢信号的归属,为其质量研究提供了参考。
The synthetic methods of three related substances of Ertapenem sodium intermediate were introduced,and their HRMS and NMR(1 H NMR,COSY,13C NMR,DEPT135°,HSQC,HMBC and D20)confirmations and the attribution of hydrocarbon signals were provided to be a reference for their quality research.
作者
金家华
王莉
王玲玲
盛力
高浩凌
JIN Jia-hua;WANG Li;WANG Ling-ling;SHENG Li;GAO Hao-ling(Zhejiang Medicine Co.,Ltd.,Xinchang Pharmaceutical Factory,Shaoxing 312500,China;Zhejiang Changhai Pharmaceutical Co.,Ltd.,Shaoxing 312500,China)
出处
《精细化工中间体》
CAS
2020年第1期39-43,共5页
Fine Chemical Intermediates
关键词
厄他培南钠
有关物质
结构确证
酰胺键
Ertapenem sodium
related substance
structure identification
amide bond
