哮喘重度急性发作63例的临床治疗观察

Clinical observation of treatment of severe acute attack of asthma 63 case

目的对比观察临床治疗中予以哮喘重度急性发作患者无创呼吸辅助治疗所具有的临床疗效及影响。方法选取永城市人民医院2015年2月-2018年10月期间接诊的哮喘重度急性发作患者63例开展回顾性研究,采用随机分组发将其分对照组32例,实验组31例。对照组患者入院后接受常规临床治疗,实验组患者在对照组治疗基础上接受无创呼吸辅助治疗。对比两组治疗前后的血气指标、炎性因子指标及治疗效果。结果观察组治疗后血清指标PaO 2(84.69±5.28)mm Hg、PaC O2(39.87±3.12)mm Hg、SaO 2(94.81±2.23)%、pH值(7.68±0.07),分别较本组治疗前和对照组治疗后有显著改善(P<0.05);两组治疗后炎性因子IL-7、IL-33和IFN-γ水平均有明显下降,且观察组治疗后IL-7(7.52±0.31)ng/L、IL-33(12.15±3.03)pg/mL和IFN-γ(711.84±117.76)pg/mL均显著低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率93.55%(29/31),明显高于对照组75.00%(24/32),差异有统计学意义(P<0.05)。结论常规治疗基础上给予无创呼吸辅助治疗哮喘重度急性发作患者,可有效缓解呼吸道内炎症和降低机体炎症反应,治疗效果显著,值得临床推广应用。

Objective To compare the clinical efficacy and effect of non-invasive respiratory adjuvant therapy in the treatment of severe acute asthma attack.Methods A retrospective study was conducted on 63 patients with severe acute attack of asthma in our hospital from February 2015 to October 2018.They were randomly divided into control group(32 cases)and experimental group(31 cases).Patients in the control group received routine clinical treatment after admission,while patients in the experimental group received non-invasive respiratory adjuvant therapy on the basis of the treatment in the control group.The blood gas index,inflammatory factor index and therapeutic effect before and after treatment were compared between the two groups.Results After treatment,the serum indexes of PaO 2(84.69±5.28)mm Hg,PaC O2(39.87±3.12)mm Hg,SaO 2(94.81±2.23)%and PH value(7.68±0.07)in the observation group were significantly improved compared with those before treatment and after treatment in the control group(P<0.05).After treatment,the levels of IL-7,IL-33 and IFN-gamma in the two groups were significantly decreased,and the levels of IL-7(7.52±0.31)ng/L,IL-33(12.15±3.03)pg/mL and IFN-gamma(711.84±117.76)pg/mL in the observation group were significantly lower than those in the control group(P<0.05).The total effective rate was 93.55%(29/31)in the observation group,which was significantly higher than 75.00%(24/32)in the control group(P<0.05).Conclusion On the basis of routine treatment,non-invasive respiratory adjuvant therapy for severe acute attack of asthma can effectively alleviate inflammation in respiratory tract and reduce inflammation reaction of body.The therapeutic effect is remarkable,and it is worthy of clinical popularization and application.