摘要
目的分析老年慢性肾脏病(chronic kidney disease,CKD)患者肾小球滤过率(glomerular filtration rate,GFR)、胱抑素C(CystatinC,CysC)和同型半胱氨酸(Homocysteine,Hcy)的相关性。方法方便选取该院在2016年12月-2018年12月共收治94例慢性肾病老年患者,依据肾小球滤过率分为早期组(GFR≥60 mL/min,n=54)和晚期组(GFR<60mL/min,n=40),对比两组CysC、Hcy变化和肾小球滤过率的关联性。结果早期组和晚期组身体质量指数(24.6±3.58)kg/m^2 vs(25.25±2.67)kg/m^2、HbA1c(8.50±2.02)%vs (8.92±2.24)%,差异无统计学意义(P>0.05),CysC(1.73±1.01)mg/L高于早期组的(0.84±0.27)mg/L,差异有统计学意义(t=6.193,P<0.05),两组Hcy (13.05±6.05)μmol/L vs (15.45±5.65)μmol/L对比,差异无统计学意义(P>0.05)。所有患者中,GFR和CysC、Hcy呈现为负相关。在CKDⅡ期、Ⅲ期患者中,GFR和CysC、HCy呈现为负相关。结论慢性肾病患者中,CysC、Hcy逐渐上升,特别在CKDⅡ、Ⅲ期,CysC、Hcy联合测定对比,能够较好地反映出慢性肾脏病肾小球滤过率功能障碍。
Objective Analysis of elderly chronic kidney disease(chronic kidney diseases,CKD) in patients with glomerular filtration rate(glomerular filtration rate,GFR) urinary inhibition,Cystatin C(CystatinC,CysC) and Homocysteine(Homocysteine,Hcy) relevance.Methods convenient selection of 94 elderly patients with chronic kidney disease were enrolled in the hospital from December 2016 to December 2018 According to the glomerular filtration rate,the patients were divided into the early group(GFR≥60 mL/min,n=54) and the late group(GFR<60 mL/min,n=40),the correlation between CysC,Hcy changes and glomerular filtration rate was compared between the two groups.Results There were no significant differences in body mass index(24.6±3.58)kg/m^2 vs(25.25±2.67) kg/m^2 and HbAlc(8.50±2.02)% vs(8.92±2.24)%between the early and late groups,the difference was not statistically significant(P>0.05).CysC(1.73±1.01) mg/L,was higher than that of the early group(0.84±0.27)mg/L,and the comparison between groups was statistically significant(t=6.193,P<0.05).There was no difference in homocysteine(Hcy)(13.05±6.05)μmol/L vs(15.45±5.65)μmol/L between the two groups(P>0.05).All the patients,the GFR and CysC,Hcy were negatively correlated.In the CKD stage II and III patients,the Hcy confirmed that GFR was negatively correlated with CysC and Hcy.Conclusion CysC,Hcy are gradually increased in patients with chronic kidney disease,especially in CKDII,III,CysC,Hcy combined,which can better reflect the glomerular filtration rate dysfunction of chronic kidney disease.
作者
崔惠芬
高土明
尹雪彬
石波
CUI Hui-fen;GAO Tu-ming;YIN Xue-bin;SHI Bo(Department of Internal Medicine,Liaobu Hospital of Guangdong Medical University,Dongguan,Guangdong Province,523400 China;Department of Emergency,Liaobu Hospital of Guangdong Medical University,Dongguan,Guangdong Province,523400 China;Department of Severe Medical,Liaobu Hospital of Guangdong Medical University,Dongguan,Guangdong Province,523400 China)
出处
《中外医疗》
2020年第5期20-21,32,共3页
China & Foreign Medical Treatment
基金
东莞市科技局社会科技发展项目(201950715039928)。
