布地奈德联合硫酸特布他林雾化吸入治疗慢性阻塞性肺疾病急性发作期患者的效果

Effects of Budesonide combined with Terbutaline sulfate aerosol inhalation in treatment of patients with chronic obstructive pulmonary disease at acute exacerbation

目的:观察布地奈德联合硫酸特布他林雾化吸入治疗慢性阻塞性肺疾病(COPD)急性发作期患者的效果。方法:选取90例COPD急性发作期患者为研究对象,按照随机数字表法分为对照组与观察组各45例。对照组给予硫酸特布他林治疗,观察组在对照组基础上给予布地奈德雾化吸入治疗。比较两组临床疗效、肺通气指标[最大呼气压(MEP)、最大吸气压(MIP)、呼气峰流速(PEF)及第一秒末用力呼气量(FEV1)]水平、肺顺应性指标[胸廓顺应性(Cth)、肺顺应性(Cl)及总顺应性(Ct)]水平以及不良反应发生率。结果:观察组治疗总有效率为93.33%,明显高于对照组的77.78%,差异有统计学意义(P<0.05);治疗后,观察组MEP、MIP、PEF、FEV1、Cth、Cl及Ct水平均明显高于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:布地奈德联合硫酸特布他林雾化吸入治疗COPD急性发作期患者可提高治疗总有效率、肺通气功能指标和肺顺应性指标水平,效果优干单纯硫酸特布他林治疗效果。

Objective:To observe effects of Budesonide combined with Terbutaline sulfate aerosol inhalation in treatment of patients with chronic obstructive pulmonary disease(COPD)at acute exacerbation.Methods:90 patients with COPD at acute exacerbation were selected as the research objects,and were divided into control group and observation group according to the random number table method,each with 45 cases.The control group was treated with Terbutaline sulfate,while the observation group was given Budesonide aerosol inhalation treatment based on that of the control group.Then,the clinical efficacy,lung ventilation index[maximum expiratory pressure(MEP),maximum inspiratory pressure(MIP),peak expiratory flow rate(PEF)and forced expiratory volume at the end of the first second(FEV1)],lung compliance indicator[thoracic compliance(Cth),lung compliance(Cl)and total compliance(Ct)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate in the observation group was 93.33%,which was significantly higher than 77.78%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of MEP,MIP,PEF,FEV1,Cth,Cl,and Ct in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:For the patients with COPD at acute exacerbation,Budesonide combined with Terbutaline sulfate aerosol inhalation can improve the total treatment effective rate,lung ventilation function index and lung compliance index levels.Moreover,it is superior to single Terbutaline sulfate.