重组人酸性成纤维细胞生长因子治疗慢性创面患儿的效果

Effects of recombinant human acidic fibroblast growth factor in treatment of children with chronic wounds

目的:观察重组人酸性成纤维细胞生长因子治疗慢性创面患儿的效果。方法:选取79例慢性创面患儿为研究对象,按照随机数字表法分为对照组40例与研究组39例。对照组接受常规治疗,研究组在对照组基础上采用重组人酸性成纤维细胞生长因子治疗。比较两组治疗后的创面愈合、肉芽生长情况,瘢痕、色素沉积发生情况。结果:治疗后,研究组创面愈合时间短于对照组,各治疗阶段创面愈合程度、肉芽生长评分均明显优于对照组,差异均有统计学意义(P<0.05);研究组创面瘢痕发生率和色素沉积发生率均明显低于对照组,瘢痕厚度、瘢痕面积和色素沉积面积均明显小于对照组,差异有统计学意义(P<0.05)。结论:在常规治疗基础上采用重组人酸性成纤维细胞生长因子治疗慢性创面患儿可缩短创面愈合时间,提高创面愈合程度评分和肉芽生长评分,降低创面瘢痕发生率和色素沉积发生率,效果优于单纯常规治疗效果。

Objective:To study effects of recombinant human acidic fibroblast growth factor in treatment of children with chronic wounds.Methods:79 children with chronic wounds were selected as the research objects,and were divided into control group(n=40)and study group(n=39)according to the random number table method.The control group received conventional treatment,while the study group was treated with recombinant human acidic fibroblast growth factor on the basis of that of the control group.The wound healing,granulation growth,scar and pigmentation after the treatment were compared between the two groups.Results:After the treatment,the wound healing time of the study group was shorter than that of the control group;the wound healing degree and granulation growth score of each treatment stage were significantly better than those of the control group;and the differences were statistically significant(P<0.05).The incidence of scars and pigmentation in the study group were significantly lower than those in the control group;the scar thickness,scar area,and pigmentation area were significantly smaller than those in the control group;and the differences were statistically significant(P<0.05).Conclusions:On the basis of the conventional treatment,the use of recombinant human acidic fibroblast growth factor in the treatment of the children with chronic wounds can shorten the wound healing time,improve the wound healing degree score and granulation growth score,and reduce the incidences of wound scars and pigmentation.Moreover,it is superior to single conventional treatment.