硫酸镁及硫酸镁联合硝苯地平治疗妊高症的治疗效果比较

Comparison of Magnesium Sulfate and Magnesium Sulfate Combined with Nifedipine in the Treatment of Pregnancy-induced Hypertension

目的对比单用硫酸镁、联用硫酸镁和硝苯地平对妊娠期高血压疾病的不同治疗效果。方法方便选取2017年4月—2019年4月期间于医院治疗妊娠期高血压疾病的80例女性患者作为该次的研究对象,以患者采用的不同治疗方案作为分组依据,将所有患者分入单用硫酸镁的对照组、联用硫酸镁和硝苯地平的研究组,每组40例。比较两组治疗前、后的血压水平以及不良反应率、妊娠结局。结果研究组治疗前舒张压、收缩压分别为(97.29±9.22)mmHg和(158.14±10.16)mmHg,与对照组(97.34±9.46)mmHg和(158.32±10.22)mmHg的舒张压、收缩压相近,差异无统计学意义(t=0.024、0.079,P=0.981、0.937>0.05)。研究组治疗后舒张压、收缩压分别为(87.72±8.66)mmHg和(123.08±9.67)mmHg,低于对照组(95.33±9.03)mmHg和(140.20±10.11)mmHg的舒张压、收缩压,差异有统计学意义(t=3.847、7.740,P=0.000、0.000<0.05)。此外,研究组仅有5.00%(2/40)的不良反应率,比对照组的35.00%(14/40)低得多,差异有统计学意义(χ^2=11.250,P=0.001<0.05)。研究组的自然分娩率为75.00%(30/40),高于对照组的45.00%(18/40),研究组的剖宫产率为25.00%(10/40),低于对照组的55.00%(22/40),差异有统计学意义(χ^2=7.500,P=0.006<0.05)。结论联用硫酸镁和硝苯地平不仅对妊娠期高血压疾病有比单用硫酸镁更好的治疗效果,其安全性也更高,因此临床推荐为患者联合应用这两种药物,以获得更好的妊娠结局。

Objective To compare the different treatment effects of magnesium sulfate alone,combined with magnesium sulfate and nifedipine on hypertension during pregnancy.Methods A total of 80 female patients who were treated for hypertension during pregnancy in the author's hospital between April 2017 and April 2019 were convenient selected as the subjects of this study.All patients were divided into different groups based on different treatment schemes.There were 40 patients in the control group using magnesium sulfate alone,and the research group using magnesium sulfate and nifedipine in combination.The blood pressure levels,adverse reaction rates,and pregnancy outcomes were compared between the two groups before and after treatment.Results The diastolic and systolic blood pressures before treatment in the study group were(97.29±9.22)mmHg and(158.14±10.16)mmHg,which were similar to those in the control group(97.34±9.46)mmHg and(158.32±10.22)mmHg,the difference was not statistically significant(t=0.024,0.079,P=0.981,0.937>0.05).The diastolic and systolic blood pressures in the study group after treatment were(87.72±8.66)mmHg and(123.08±9.67)mmHg,which were lower than those in the control group(95.33±9.03)mmHg and(140.20±10.11)mmHg.There was statistical significance(t=3.847,7.740,P=0.000,0.000<0.05).In addition,the adverse reaction rate in the study group was only 5.00%(2/40),which was much lower than the 35.00%(14/40)in the control group,and the difference was statistically significant(χ^2=11.250,P=0.001<0.05).The natural delivery rate in the study group was 75.00%(30/40),which was higher than 45.00%(18/40)in the control group.The cesarean delivery rate in the study group was 25.00%(10/40),which was lower than 55.00%(22/40)in the control group,the difference was statistically significant(χ^2=7.500,P=0.006<0.05).Conclusion The combined use of magnesium sulfate and nifedipine not only has a better therapeutic effect on hypertensive disorders of pregnancy than magnesium sulfate alone,but also has a higher safety.Therefore,it is clinically recommended that patients use these two drugs in combination to obtain better pregnancy outcomes.