低血清维生素D水平与动脉粥样硬化关系研究进展

Research Progress on the Relationship between Low Serum Vitamin D Level and Atherosclerosis

长久以来,维生素D在维持人体钙稳态、促使骨骼健康与预防骨折方面具有经典作用。新近的研究显示,维生素D可能通过多种机制参与并影响动脉粥样硬化的发展。在以动脉粥样硬化为病理基础的心血管疾病的发展方面,低维生素D作为新的潜在的危险因素,具有重要研究意义。关于维生素D与动脉粥样硬化之间的关联性调查在过去十年中已经呈现出巨大的发展势头,该文将在总结国内外相关临床研究和实验数据的基础上,对二者之间的生物学联系及研究进展作一综述。

For a long time,vitamin D has a classic role in maintaining calcium homeostasis,promoting bone health and preventing fractures.Recent studies have shown that vitamin D may participate in and affect the development of atherosclerosis through a variety of mechanisms.In the development of cardiovascular disease based on atherosclerosis,low vitamin D as a new potential risk factor has important research significance.The investigation on the relationship between vitamin D and atherosclerosis has shown great development momentum in the past decade.This article will summarize the clinical research and experimental data at home and abroad on the basis of the biological relationship between the two.A review of the academic links and research progress was made.