高氨血症早产儿的发病特点、治疗方法及预后分析

High Blood Ammonia Analysis the Clinical Characteristic, Treatment Method and Prognosis of Premature Infants

目的研究高氨血症早产儿的发病特点、治疗方法及预后分析,为高氨血症早产儿的治疗提供理论依据。方法方便收集该院2017年1月-2019年1月治疗的190例高氨血症早产儿的临床资料作为研究组,并按照不同胎龄分为3组,对照组为同期足月的正常新生儿190名。采用病例对照研究的方法,比较高氨血症早产儿发病特点、血氨检查结果、治疗方法及预后分析。结果高氨血症患儿主要临床特点为吸吮无力、意识障碍、呕吐、喂养困难以及血常规异常;研究组血氨水平显著高于对照组,且研究组中血氨水平随着胎龄和体重的降低而升高;采取的治疗方法主要有禁食、使用血制品、使用气管插管等;预后死亡率为3.69%,缓解后自动出院占比48.42%,治愈出院占比47.89%。结论及时掌握了解高氨血症早产儿特点并及时治疗,预后效果良好。

Objective To study the clinical characteristic of high blood ammonia premature babies, treatment and prognosis analysis, provide theoretical basis for the treatment of high blood ammonia premature babies. Methods Convenient select in the hospital in January 2017 to January 2019 for the treatment of the clinical data of 190 cases of high blood ammonia premature babies as a team, and according to the different gestational age is divided into three groups, control group and 190 cases of normal full-term newborns for the same period. With the method of case-control study, relatively high blood ammonia premature disease characteristics, blood ammonia, treatment and prognosis analysis test results. Results Children with high blood ammonia main clinical features for sucking weakness, disturbance of consciousness, vomiting, feeding difficulties, and routine blood exception;the team of blood ammonia level is significantly higher than the control group, and the team of blood ammonia levels increased with gestational age and weight reduction;take fasting, main treatment methods of use of blood products, the use of endotracheal intubation, etc;prognosis of mortality was 3.69%, alleviate automatically after hospital discharge accounted for 48.42%, cure the hospital accounted for 47.89%. Conclusion Timely understanding of the characteristics of premature hyperammonia-emia and timely treatment have a good prognosis.