格列吡嗪控释片治疗老年2型糖尿病的临床效果及药理作用分析

Clinical Effect and Pharmacological Effects of Glipizide Controlled-release Tablets in the Treatment of Elderly Patients with Type 2 Diabetes

目的分析格列吡嗪控释片治疗老年2型糖尿病的临床效果及药理作用。方法2017年3月—2018年3月间随机分组,对照组常规给予二甲双胍治疗,观察组给予格列吡嗪控释片治疗。结果观察组治疗后FPG(5.6±0.6)mmol/L、P2 hPG(8.4±0.7)mmol/L、HbA1c(7.1±0.7)%、TC(4.1±0.6)mmol/L、TG(2.0±0.5)mmol/L、LDL(2.1±0.3)mmol/L、有效率96.7%、不良反应3.3%、并发症占3.3%。对照组治疗后FPG(8.1±0.4)mmol/L、P2 hPG(10.6±1.6)mmol/L、HbA1c(10.3±2.6)%、TC(5.6±0.8)mmol/L、TG(2.5±0.2)mmol/L、LDL(3.0±0.3)mmol/L、有效率70.0%、不良反应20.0%、并发症占23.3%。两组相比,差异有统计学意义(P<0.05)。结论采用格列吡嗪控释片治疗老年2型糖尿病,有效率高,不良反应少,可在降血糖的同时,实现对血脂水平的控制,预防并发症,改善预后。

Objective To analyze the clinical effect and pharmacological effects of glipizide controlled-release tablets in the treatment of elderly patients with type 2 diabetes.Methods From March 2017 to March 2018 The patients were randomly divided into two groups.The control group was routinely given metformin and the observation group was given glipizide controlled-release tablets.Results After treatment in the observation group,FPG(5.6±0.6)mmol/L,P2 hPG(8.4±0.7)mmol/L,HbA1c(7.1±0.7)%,TC(4.1±0.6)mmol/L,and TG(2.0±0.5)mmol/L,LDL(2.1±0.3)mmol/L,effective rate 96.7%,adverse reactions 3.3%,and complications accounted for 3.3%.The control group was treated with FPG(8.1±0.4)mmol/L,P2hPG(10.6±1.6)mmol/L,HbA1c(10.3±2.6)%,TC(5.6±0.8)mmol/L,and TG(2.5±0.2)mmol/L,LDL(3.0±0.3)mmol/L,effective rate 70.0%,adverse reactions 20.0%,and complications accounted for 23.3%.Compared with the two groups,the difference was statistically significant(P<0.05).Conclusion Glipizide controlled-release tablets for the treatment of elderly patients with type 2 diabetes mellitus have high efficiency and few adverse reactions.They can lower blood glucose,control blood lipid levels,prevent complications,and improve prognosis.