CD138对慢性子宫内膜炎合并不孕患者的诊断价值

Diagnostic Value of CD138 in Patients with Chronic Endometritis and Infertility

目的评估膜硫酸乙酰肝素蛋白多糖配体蛋白聚糖-1(CD138)运用在慢性子宫内膜炎并存不孕患者诊断中的临床诊断价值。方法对2018年6月—2019年2月该院收治的78例不孕患者资料予以指标研究调查,均实行宫腹腔镜手术,先采取常规苏木精伊红染色方法检测,之后采取CD138免疫组化染色方法检测,术后对所有不孕患者予以辅助妊娠治疗,分析结果。结果不孕患者采取CD138免疫组化染色方法的慢性子宫内膜炎阳性检出合计率(34.62%)高于常规苏木精伊红染色方法(20.51%)(χ2=4.238,P<0.05);CD138阴性不孕患者的妊娠合计率(31.37%)高于CD138阳性不孕患者(7.41%)(χ2=6.505,P<0.05)。结论应用CD138免疫组化染色方法有助于慢性子宫内膜炎并存不孕患者的临床诊断。

Objective To evaluate the clinical diagnostic value of membrane heparan sulfate proteoglycan ligand proteoglycan-1(CD138)in the diagnosis of patients with chronic endometritis and infertility.Methods The data of 78 infertile patients admitted to the hospital from June 2018 to February 2019 were indexed and investigated.All patients underwent laparoscopic surgery.They were first tested with conventional hematoxylin and eosin staining methods,and then CD138 immunization group was used.The staining method was used to detect all infertility patients.Results The total positive rate of chronic endometritis with CD138 immunohistochemical staining in infertile patients(34.62%)was higher than that in conventional hematoxylin and eosin staining(20.51%)(χ2=4.238,P<0.05);the total pregnancy rate of CD138-negative infertility patients(31.37%)was higher than that of CD138-positive infertility patients(7.41%)(χ2=6.505,P<0.05).Conclusion The application of CD138 immunohistochemical staining is helpful for the clinical diagnosis of infertility patients with chronic endometritis.