卡前列素氨丁三醇对孕产妇产后出血的治疗效果及不良反应研究

Study on the Therapeutic Effect and Adverse Reactions of Carboprost Tromethamine on Postpartum Hemorrhage in Pregnant Women

目的分析探究卡前列素氨丁三醇对孕产妇产后出血治疗效果及不良反应的影响。方法此次研究采取随机盲选法,将2018年6月—2019年6月该院收治的78例产后出血孕产妇划分为2组,各组平均39例;其中,对照组实行常规治疗,观察组实行卡前列素氨丁三醇治疗,对比2组孕产妇的临床疗效、临床指标及不良反应发生率。结果①观察组治疗有效率(94.87%)明显高于对照组(74.36%)(χ2=9.287,P<0.05)。②观察组,止血时间为(15.22±2.12)min、产后2 h出血量为(271.53±12.08)mL、HAMD评分为(11.37±2.15)分、血性恶露持续时间(4.31±1.14)d;对照组,止血时间为(35.41±3.48)min、产后2 h出血量为(545.11±14.23)mL、HAMD评分为(15.83±3.28)分、血性恶露持续时间(6.88±1.23)d。结合数据可知,观察组止血时间、血性恶露持续时间均明显短于对照组,观察组产后2 h出血量明显少于对照组,观察组HAMD评分则明显低于对照组(t=10.456、12.398、6.185、5.127,P<0.05)。③观察组、对照组不良反应发生率分别为2.56%、20.51%,观察组明显要比对照组低(χ2=11.593,P<0.05)。结论孕产妇产后出血实行卡前列素氨丁三醇治疗的效果显著,能明显提高治疗效果,减少产后出血量及血性恶露持续时间,大大降低不良反应发生率。

Objective To analyze the effects of carboprost tromethamine on the treatment effect and adverse effects of postpartum hemorrhage in pregnant women.Methods The randomized blind selection method was used in this study.The 78 pregnant women with postpartum hemorrhage treated in the hospital from June 2018 to June 2019 were divided into two groups,with an average of 39 in each group.Among them,the control group received conventional treatment and the observation group was treated with carboprost tromethamine,and the clinical efficacy,clinical indicators and incidence of adverse reactions were compared between the two groups.Results 1.The effective rate of treatment in the observation group(94.87%)was significantly higher than that in the control group(74.36%)(χ2=9.287,P<0.05).2.In the observation group,the hemostatic time was(15.22±2.12)min,the post-partum hemorrhage volume was(271.53±12.08)mL,the HAMD score was(11.37±2.15)points,and the duration of blood lochia was wei(4.31±1.14)d;In the control group,the time of hemostasis was(35.41±3.48)min,the amount of bleeding at 2 h postpartum was(545.11±14.23)mL,the HAMD score was(15.83±3.28)points,and the duration of bloody lochia was(6.88±1.23)d.Combining the data,it can be seen that the hemostatic time and the duration of bloody lochia in the observation group were significantly shorter than those in the control group.The 2 h postpartum hemorrhage in the observation group was significantly less than that in the control group(t=10.456,12.398,6.185,5.127,P<0.05).3.The incidences of adverse reactions in the observation group and the control group were 2.56%and 20.51%,respectively.The observation group was significantly lower than the control group(χ2=11.593,P<0.05).Conclusion Carboprost tromethamine is effective in treating postpartum hemorrhage of pregnant women.It can significantly improve the treatment effect,reduce the amount of postpartum hemorrhage and the duration of bloody lochia,and greatly reduce the incidence of adverse reactions.