低剂量右美托咪定与酒石酸布托啡诺复合应用于乳腺癌根治术后静脉镇痛中的效果分析

Analysis of the Effect of Low-dose Dexmedetomidine Combined with Butorphin Tartrate in Intravenous Analgesia after Radical Mastectomy

目的探讨低剂量右美托咪定与酒石酸布托啡诺复合应用于乳腺癌根治术后静脉镇痛中的效果。方法选择2017年12月—2019年12月于该院行乳腺癌根治术后患者65例,以随机数表法对其进行分组,分为对照组32例与研究组33例。对照组术后应用酒石酸布托啡诺静脉镇痛,研究组术后应用低剂量右美托咪定与酒石酸布托啡诺复合静脉镇痛。对比两组术后24 h、48 h视觉模拟评分(VAS)、Ramsay镇静评分的变化,以及两组术后静脉镇痛泵的按压频次、镇痛相关不良反应情况。结果研究组术后24 h、48 h时VAS评分(3.2±0.5)分、(2.6±0.3)分均低于对照组(3.8±0.4)分、(3.2±0.3)分(t=5.332、8.061,P<0.01)。对照组术后24 h、48 h时Ramsay评分(2.0±0.2)分、(1.8±0.3)分高于研究组(1.4±0.3)分、(1.2±0.5)分(t=9.515、5.887,P<0.01)。研究组静脉镇痛泵按压频次为(7.4±1.2)次,低于对照组(11.2±2.0)次(t=9.322,P<0.01)。研究组镇痛相关不良反应的发生率为15.15%与对照组15.63%对比差异无统计学意义(χ2=0.003,P>0.05)。结论低剂量右美托咪定与酒石酸布托啡诺复合应用于乳腺癌根治术后静脉镇痛中具有显著的应用效果。

Objective To investigate the effect of low-dose dexmedetomidine combined with butorphin tartrate on venous analgesia after radical mastectomy.Methods A total of 65 patients who underwent radical mastectomy for breast cancer in the hospital from December 2017 to December 2019 were selected and grouped by random number table.They were divided into 32 cases in the control group and 33 cases in the study group.The control group was treated with butorphanol tartrate for intravenous analgesia,and the study group was treated with low-dose dexmedetomidine and butorphin tartrate for intravenous analgesia.The changes of visual analogue score(VAS)and Ramsay sedation score at 24 h and 48 h after operation were compared between the two groups.Results The scores of VAS(3.2±0.5)points and(2.6±0.3)points at 24 h and 48 h after study were lower than those of the control group(3.8±0.4)points and(3.2±0.3)points(t=5.332,8.061,P<0.01).At 24 h and 48 h after surgery,the Ramsay scores(2.0±0.2)points and(1.8±0.3)points were in the control group lower than those in the observation group(1.4±0.3)points and(1.2±0.5)points(t=9.515,5.887,P<0.01).The frequency of venous analgesia pump compression in the study group was(7.4±1.2)times,which was lower than that in the control group(11.2±2.0)times(t=9.322,P<0.01).The incidence of analgesic-related adverse reactions in the study group was 15.15%and there was no statistically significant difference between the control group and 15.63%(χ2=0.003,P>0.05).Conclusion The combination of low-dose dexmedetomidine and butorphanol tartrate in intravenous analgesia after radical mastectomy has significant application effects.