克林霉素、复方磺胺甲噁唑片联用对艾滋病合并肺孢子菌肺炎的疗效分析

Clindamycin and Compound Sulfamethoxazole Tablets in Combination with Pneumocystis Pneumoniae and AIDS

目的分析克林霉素、复方磺胺甲噁唑片联用对艾滋病合并肺孢子菌肺炎的疗效。方法随机观察该院收治的76例艾滋病合并肺孢子菌肺炎患者,研究进行时间为2016年8月—2018年9月,随机将患者分成两组,一组采用复方磺胺甲噁唑片治疗,为常规组,一组联合克林霉素用药,为观察组,对比两组患者的临床疗效和实验室指标。结果观察组患者中有34例患者治疗有效,有效率为89.47%,数据与常规组比较差异有统计学意义(χ2=4.070,P=0.044);观察组患者治疗后PaO2为(84.64±3.84)mmHg,SaO2为(90.22±4.38)%,乳酸脱氢酶为(324.85±28.38)U/L,白蛋白水平为(37.26±4.82)g/L,各项数据与常规组对比差异有统计学意义(t=9.989,P=0.000;t=13.062,P=0.000,t=18.530,P=0.000,t=5.887,P=0.000);观察组患者躯体质量评分为(62.2±4.4)分,心理健康评分为(65.9±4.9)分,社会功能评分为(61.6±3.7)分,情感功能评分为(66.6±5.7)分,其数据与常规组差异有统计学意义(t=11.582,P=0.000;t=5.012,P=0.000;t=9.053,P=0.000;t=7.070,P=0.000)。结论克林霉素、复方磺胺甲噁唑片联用对艾滋病合并肺孢子菌肺炎的治疗效果非常显著,可有效改善患者血气指标,降低乳酸脱氢酶和白蛋白水平,减轻患者临床症状,改善预后,提升患者生活质量。

Objective To analyze the curative effect of combination of clindamycin and compound sulfamethoxazole tablets on AIDS combined with pneumocystis pneumonia.Methods Randomly observe 76 patients with AIDS and pneumocystis pneumonia treated in the hospital.The study period was from August 2016 to September 2018.The patients were randomly divided into two groups.For the routine group,one group was administered with clindamycin,and for the observation group,the clinical efficacy and laboratory indicators of the two groups were compared.Results 34 patients in the observation group were treated effectively,with an effective rate of 89.47%.The data were statistically significant compared with the conventional group(χ2=4.070,P=0.044);PaO2 after treatment in the observation group was(84.64±3.84)mmHg,SaO2 was(90.22±4.38)%,lactate dehydrogenase was(324.85±28.38)U/L,albumin level was(37.26±4.82)g/L,and the data were statistically significant compared with the conventional group(t=9.989,P=0.000,t=13.062,P=0.000;t=18.530,P=0.000;t=5.887,P=0.000);the body mass score of patients in the observation group was(62.2±4.4)points,the mental health score was(65.9±4.9)points,the social function score was(61.6±3.7)points,and the emotional function score was(66.6±5.7)points.The data were significantly different from the conventional group(t=11.582,P=0.000;t=5.012,P=0.000;t=9.053,P=0.000,t=7.070,P=0.000).Conclusion The combination of clindamycin and compound sulfamethoxazole tablets for AIDS combined with pneumocystis pneumonia is very effective.It can effectively improve the blood gas index of patients,reduce lactate dehydrogenase and albumin levels,and reduce clinical symptoms.It is worth using to improve the prognosis and the quality of life of patients.