IL-6R与支气管哮喘研究进展

Research Progress of IL-6R and Bronchial Asthma

白细胞介素-6R是一种细胞因子受体,由2个跨膜糖蛋白(α、β链)组成,广泛分布于细胞膜上。参与各种免疫反应的发生发展。近年研究发现IL-6R与哮喘发病有关。其可以通过IL-6/mIL-6R的经典信号通路,IL-6/sIL-6R复合物信号发挥作用,在哮喘发病过程中起到抑制增殖、调节诱导细胞分化、增加气道粘液、加重气道炎症、促进纤维化等作用。

Interleukin-6R is a cytokine receptor composed of two transmembrane glycoproteins(αandβchains),which are widely distributed on cell models.Involved in the development of various immune responses.Recent studies have found that IL-6R is associated with the onset of asthma.It can play a role through the classic signaling pathway of IL-6/mIL-6R and the signal of IL-6/sIL-6R complex,which can inhibit proliferation,regulate and induce cell differentiation,increase airway mucus,and aggravate gas during the onset of asthma inflammation,promote fibrosis and so on.