氯氧喹治疗晚期非小细胞肺癌的临床效果分析

Clinical Effect of Chloroquine on Advanced Non-small Cell Lung Cancer

目的探讨氯氧喹治疗晚期非小细胞肺癌的临床效果。方法该院2017年11月—2019年6月收治的100例晚期非小细胞肺癌患者随机分为两组,各50例,氯氧喹组给予氯氧喹治疗,常规化疗方案治疗组采用常规化疗方案,对比两组晚期非小细胞肺癌患者的总缓解率和疾病控制率、1年生存率及欧洲癌症研究与治疗组织生命质量测定量表评分、信号通路分子水平。结果氯氧喹组疗效88.00%明显优于常规化疗方案治疗组76.00%,差异有统计学意义(χ2=8.044,P<0.05)。氯氧喹组1年生存率82.00%高于常规化疗方案治疗组52.00%(P<0.05)。氯氧喹组欧洲癌症研究与治疗组织生命质量测定量表评分(69.21±11.21)分高于常规化疗方案治疗组(55.21±10.66)分(t=4.168,P<0.05)。常规化疗方案治疗组信号通路分子水平AKT、PI13K、MAPK、ERK1、ERK2、JAK2、STAT3分别是(0.24±0.02)、(0.34±0.01)、(0.18±0.02)、(0.22±0.06)、(0.35±0.02)、(0.13±0.05)、(0.42±0.02),低于氯氧喹组(1.04±0.12)、(1.05±0.21)、(1.13±0.14)、(1.01±0.14)、(1.05±0.21)、(1.13±0.25)、(1.35±0.25)(t=7.215、4.156、5.257、5.621、6.221、4.578、4.226,P<0.05)。结论采用氯氧喹治疗晚期非小细胞肺癌具有良好的治疗效果,可更好提高治疗效果,提高1年生存率,并提高晚期非小细胞肺癌患者的生存质量水平以及改善信号通路因子水平。

Objective To investigate the clinical effect of chloroquine in the treatment of advanced non-small cell lung cancer.Methods One hundred patients with advanced non-small cell lung cancer admitted to our hospital from November 2017 to June 2019 were randomly divided into two groups,50 patients in each group,chloroquine group in the chlorooxyquine group,and conventional chemotherapy regimen in the treatment group.The chemotherapy regimen was used to compare the overall response rate and disease control rate,1-year survival rate,and the european cancer research and treatment tissue quality of life measurement scale score and signal pathway molecular level in the two groups of patients with advanced non-small cell lung cancer.Results The efficacy of chlorooxyquine group was 88.00%,which was significantly better than that of conventional chemotherapy regimen 76.00%,the difference was statistically significant(χ2=8.044,P<0.05).The 1-year survival rate of chloroquine group was 82.00%higher than that of conventional chemotherapy regimen 52.00%(P<0.05).The chloroquine group european cancer research and treatment tissue quality of life measurement scale score(69.21±11.21)points higher than the conventional chemotherapy regimen treatment group(55.21±10.66)points(t=4.168,P<0.05).The molecular levels of the conventional chemotherapy regiment reatment group signaling pathways AKT,PI13K,MAPK,ERK1,ERK2,JAK2,and STAT3 were(0.24±0.02),(0.34±0.01),(0.18±0.02),(0.22±0.06),(0.35±0.02),(0.13±0.05),(0.42±0.02),and(0.42±0.02),lower than the chloroquine group(1.04±0.12),(1.05±0.21),(1.13±0.14),(1.01±0.14),(1.05±0.21),(1.13±0.25),(1.35±0.25)(t=7.215,4.156,5.257,5.621,6.221,4.578,4.226,P<0.05).Conclusion The use of chloroquine in the treatment of advanced non-small cell lung cancer has a good therapeutic effect,can improve the treatment effect,improve the 1-year survival rate,and improve the quality of life of patients with advanced non-small cell lung cancer and improve the level of signaling pathway factors.