连续性肾脏替代疗法对多器官功能障碍综合征患者的疗效分析

Effect of Continuous Renal Replacement Therapy on Patients with Multiple Organ Dysfunction Syndrome

目的探讨连续性肾脏替代疗法对多器官功能障碍综合征患者的疗效。方法选取该院2017年1月—2019年10月所收治的90例多器官功能障碍综合征患者,将入选患者随机分为研究组和对照组,每组45例患者,对照组患者采取常规治疗,研究组患者在对照组基础上联合连续性肾脏替代疗法,对比疗效。结果研究组患者MAP(66.81±7.13)mmHg、CI(5.03±0.87)L/(min·m^2)、HR(84.81±9.32)次/min明显优于对照组(60.31±6.42)mmHg、(4.65±0.72)L/(min·m^2)、(95.41±10.54)次/min(t=4.540、2.260、5.050,P<0.05);研究组患者Scr(287.9±113.4)μmol/L、BUN(15.3±4.2)mmol/L、CRP(36.18±17.23)mg/L、Lac(1.03±0.35)mmol/L明显低于对照组(375.4±142.1)μmol/L、(20.8±6.2)mmol/L、(63.28±13.21)mg/L、(2.53±0.81)mmol/L(t=3.230、4.930、8.370、18.210,P<0.05);研究组患者治疗30 d后病死率33.3%明显对照组64.4%(χ^2=10.352,P<0.05)。结论多器官功能障碍综合征患者采取连续性肾脏替代疗法,有助于稳定机体血流动力学水平,调节血液生化指标,调节机体内环境,降低短期死亡率,适用于危重症患者,值得临床上深入研究。

Objective To investigate the effect of continuous renal replacement therapy on patients with multiple organ dysfunction syndrome.Methods 90 patients with multiple organ dysfunction syndrome treated in the hospital from January 2017 to October 2019 were randomly divided into a study group and a control group,with 45 patients in each group.The patients in the control group received conventional treatment.Patients in the study group combined continuous renal replacement therapy on the basis of the control group to compare the effects.Results The MAP(66.81±7.13)mm Hg,CI(5.03±0.87)L/(min·m^2),and HR(84.81±9.32)times/min min in the study group were significantly better than those in the control group(60.31±6.42)mmHg,(4.65±0.72)L/(min·m^2),(95.41±10.54)times/min(t=4.540,2.260,5.050,P<0.05);Scr(287.9±113.4)μmol/L,BUN(15.3±4.2)mmol/L in the study group,CRP(36.18±17.23)mg/L,Lac(1.03±0.35)mmol/L were significantly lower than the control group(375.4±142.1)μmol/L,(20.8±6.2)mmol/L,(63.28±13.21)mg/L,(2.53±0.81)mmol/L(t=3.230,4.930,8.370,18.210,P<0.05);mortality in the study group was 33.3%after treatment for 30 d,and 64.4%in the control group(χ^2=10.352,P<0.05).Conclusion Continuous renal replacement therapy in patients with multiple organ dysfunction syndrome can help stabilize the body's hemodynamic level,regulate blood biochemical indicators,regulate the body's environment,and reduce short-term mortality.It is suitable for critically ill patients and is worth clinical In-depth research.