妊娠合并亚临床甲状腺功能减退症的早期治疗对妊娠结局的影响效果分析

Effect of Early Treatment of Pregnancy with Subclinical Hypothyroidism on Pregnancy Outcome

目的分析妊娠合并亚临床甲状腺功能减退症的早期治疗对妊娠结局的影响效果。方法研究对该院近期收治的356例妊娠合并亚临床甲状腺功能减退症患者进行了观察,患者入组时间为2018年5月—2019年2月,采用数字随机法将患者分成普通组和研究组,研究组给予早期治疗措施,普通组仅给予早期护理干预措施,对比两组患者的并发症、妊娠结局和甲状腺功能。结果研究组患者并发症发生率为4.49%(8例),普通组患者并发症发生率为17.42%(31例),两组患者并发症数据对比差异有统计学意义(χ^2=15.233,P<0.05)。研究组患者不良妊娠结局发生率为6.74%(12例),普通组患者不良妊娠结局发生率为15.73%(28例),两组不良妊娠结局对比差异有统计学意义(χ^2=7.210,P<0.05);研究组患者干预后TSH为(2.76±0.47)mU/L,FT3为(5.59±1.52)pmol/L,FT4为(18.12±3.18)pmol/L,总三碘甲状腺激素为(2.50±0.44)nmol/L,各项数据与普通组比较差异有统计学意义(t=25.818、19.189、13.913、32.747,P<0.05)。结论妊娠合并亚临床甲状腺功能减退症可导致流产等不良妊娠结局,并可能引起多种并发症,通过实施早期治疗,可降低不良妊娠结局和并发症发生率,改善患者甲状腺功能。

Objective To analyze the effect of early treatment of pregnancy with subclinical hypothyroidism on pregnancy outcome.Methods The study examined 356 patients with subclinical hypothyroidism who were pregnant recently in the hospital.The patients were enrolled from May 2018 to February 2019.The patients were divided into ordinary groups by digital random method and the study group was given early treatment measures,and the general group was given only early care interventions.The complications,pregnancy outcomes and thyroid function were compared between the two groups.Results The complication rate of patients in the study group was 4.49%(8 cases),and the complication rate of patients in the general group was 17.42%(31 cases).The complication data of the two groups were statistically significant(χ^2=15.233,P<0.05).The incidence of adverse pregnancy outcomes in the study group was 6.74%(12 cases),and the incidence of adverse pregnancy outcomes in the general group was 15.73%(28 cases).There was a statistically significant difference in adverse pregnancy outcomes between the two groups(χ^2=7.210,P<0.05);TSH of the study group patients after intervention was(2.76±0.47)mU/L,FT3 was(5.59±1.52)pmol/L,FT4 was(18.12±3.18)pmol/L,and total triiodothyroxine was(2.50±0.44)nmol/L,the data are statistically significant compared with the ordinary group(t=25.818、19.189、13.913、32.747,P<0.05).Conclusion Preclinical pregnancy with subclinical hypothyroidism can lead to adverse pregnancy outcomes such as miscarriage,and may cause a variety of complications.Early treatment can reduce the incidence of adverse pregnancy outcomes and complications,and improve thyroid function in patients.