维A酸乳膏联合重组人干扰素α-2b凝胶治疗扁平疣疗效的影响

Effect of Vitamin A Acid Cream Combined with Recombinant Human Interferonα-2b Gel in the Treatment of Flat Warts

目的分析扁平疣采用维A酸乳膏联合重组人干扰素α-2b凝胶治疗的临床疗效。方法选取该院2018年7月—2019年7月收治的84例扁平疣患者为研究对象,按照随机数字表法分为两组,对照组仅采用维A酸乳膏治疗,观察组在对照组基础上联合重组人干扰素α-2b凝胶治疗,对比两组临床疗效、治疗前后T淋巴细胞亚群指标变化情况以及不良反应发生情况。结果观察组治疗总有效率为95.23%,高于对照组的71.43%(χ^2=8.571,P<0.05);观察组治疗后CD4^+、CD8^+、CD4^+/CD8^+分别为(44.28±2.28)%、(30.02±1.98)%、(1.52±0.38),均高于对照组(t=12.148、13.259、10.256,P<0.05);对照组不良反应发生率为21.43%(9/42),观察组为23.81%(10/42),对比差异无统计学意义(χ^2=0.068,P>0.05)。结论扁平疣采用维A酸乳膏联合重组人干扰素α-2b凝胶治疗的临床疗效显著,且安全性高。

Objective To analyze the clinical effect of flat warts treated with vitamin A acid cream combined with recombinant human interferonα-2b gel.Methods 84 patients with flat wart treated in our hospital from July 2018 to July 2019 were selected as the research subjects.They were divided into two groups according to the random number table method.The control group was treated with vitamin A acid cream only,and the observation group was in the control group.Based on the combination of recombinant human interferonα-2b gel treatment,the clinical efficacy,changes in T lymphocyte subpopulation indicators before and after treatment,and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.23%,which was higher than 71.43%in the control group(χ^2=8.571,P<0.05);CD4^+,CD8^+,and CD4^+/CD8^+in the observation group were(44.28±2.28)%and(30.02±1.98)%and(1.52±0.38)after treatment were higher than those in the control group(t=12.148,13.3259,10.256,P<0.05);the incidence of adverse reactions in the control group was 21.43%(9/42),and the observation group was 23.81%(10/42),and the difference was not statistically significant(χ^2=0.068,P>0.05).Conclusion The treatment of flat warts with vitamin A acid cream combined with recombinant human interferonα-2b gel has significant clinical efficacy and high safety.