肾上腺皮质激素治疗脊髓炎的效果与安全性评价

The Effect and Safety of Adrenocortical Hormone on Myelitis

目的对在脊髓炎的临床治疗中应用肾上腺皮质激素的效果进行探究。方法选择该院收治的70例急性脊髓炎患者作为该次研究纳入的对象,选取时间段为2018年1月—2019年5月,按照随机数字表法将这些患者划分为试验组和参照组,每组35例患者。采用常规基础治疗的方式对其中的参照组患者予以治疗,在此基础之上,通过肾上腺皮质激素对试验组患者予以治疗。在治疗完成后,对两组患者的治疗效果和不良反应进行观察和比较。结果参照组中有9例治愈,12例显效,7例有效,7例无效,总有效率为80.0%,试验组中有14例治愈,15例显效,5例有效,1例无效,总有效率为97.1%。试验组的总有效率明显高于参照组,经过检验,差异有统计学意义(χ^2=8.462,P<0.05)。参照组的排尿恢复时长为(12.3±3.5)d,肢体肌力恢复时长为(15.6±2.7)d,感觉恢复时长为(9.1±2.3)d,独立行走恢复时长为(26.2±2.6)d,试验组的排尿恢复时长为(7.2±1.8)d,肢体肌力恢复时长为(8.1±1.4)d,感觉恢复时长为(5.1±1.2)d,独立行走恢复时长为(14.9±3.7)d。试验组的症状改善时间均明显优于参照组,经过检验,差异有统计学意义(t=3.461、3.886、3.573、3.602,P<0.05)。参照组中共计有3例胃肠反应,1例头晕,2例失眠,共计达到了17.1%的不良反应发生率,试验组中共计有1例胃肠反应,1例头晕,共计达到了5.7%的不良反应发生率。试验组的不良反应率明显高于参照组,经过检验,差异有统计学意义(χ^2=6.734,P<0.05)。结论针对急性脊髓炎患者采用肾上腺皮质激素进行治疗具有很好的效果,而且不良反应少。

Objective To investigate the effect of applying adrenocortical hormone in the clinical treatment of myelitis.Methods 70 patients with acute myelitis treated in the hospital were selected as the subjects included in this study.The period was selected from January 2018 to May 2019.These patients were divided into test group and reference group according to the random number table method.There were 35 patients in each group.Patients in the reference group were treated with conventional basic treatment.On this basis,patients in the test group were treated with adrenocortical hormone.After the treatment was completed,the treatment effects and adverse reactions of the two groups of patients were observed and compared.Results In the reference group,9 cases were cured,12 cases were markedly effective,7 cases were effective,7 cases were ineffective,and the total effective rate was 80.0%.In the test group,14 cases were cured,15 cases were markedly effective,5 cases were effective,and 1 case was not effective.The efficiency was 97.1%.The total effective rate of the test group was significantly higher than that of the reference group.After inspection,the difference was statistically significant(χ^2=8.462,P<0.05).The duration of urination recovery in the reference group was(12.3±3.5)d,the duration of limb muscle strength recovery was(15.6±2.7)d,the duration of sensory recovery was(9.1±2.3)d,and the recovery time of independent walking was(26.2±2.6)d.The duration of urination recovery in the test group was(7.2±1.8)d,the recovery time of limb muscle strength was(8.1±1.4)d,the recovery time of sensory recovery was(5.1±1.2)d,and the recovery time of independent walking was(14.9±3.7)d.The time to improve symptoms in the test group was significantly better than that in the reference group.After testing,the difference was statistically significant(t=3.461,3.886,3.573,3.602,P<0.05).There were 3 cases of gastrointestinal reactions in the reference group,1 case of dizziness,2 cases of insomnia,a total of 17.1%of adverse reactions,and 1 case of gastrointestinal reactions,1 case of dizziness,a total of 5.7%in the test group.Incidence of adverse reactions.The adverse reaction rate in the experimental group was significantly higher than that in the reference group.After inspection,the difference was statistically significant(χ^2=6.734,P<0.05).Conclusion Adrenocortical hormone therapy for patients with acute myelitis has a good effect,and there are fewer adverse reactions.