云南省昆明市新型冠状病毒感染患者早期特征分析

Analysis of early characteristics of patients with novel coronavirus infection in Kunming City,Yunnan Province,China

目的分析昆明市新型冠状病毒(2019-nCoV)感染患者的流行病学特征和早期临床特征,为临床的诊治提供依据。方法对2020年1月23日至2月10日昆明市第三人民医院隔离病房收治的41例2019-nCoV确诊患者的流行病学史、临床症状、实验室检测资料进行回顾性分析。结果41例2019-nCoV确诊患者绝大多数为输入性病例,潜伏期2~20 d不等;重型和危重型患者与轻型和普通型患者比较年龄更大、BMI更高、临床症状相似、淋巴细胞计数更低、血气变化更早、血沉更高、CA和FE更低及CD4、CD8计数下降更明显。结论淋巴细胞计数、血气变化、血沉、CA和FE及T淋巴细胞亚群在病情加重前1周内会更早的出现变化,对病情的轻重有一定的预警作用。

To analyze the epidemiological characteristics and early clinical characteristics of patients with new coronavirus(2019-nCoV)infection in Kunming,and to provide evidence for clinical diagnosis and treatment.The epidemiological history,clinical symptoms,and laboratory test data of 41 of 2019-nCoV confirmed patients admitted to the isolation ward of The third People’s Hospital of Kunming from January 23 to February 10,2020 were retrospectively analyzed.The vast majority of 412019-nCoV confirmed patients were imported cases,with incubation periods ranging from 2 to 20 days;severe and critically ill patients were Severe and critically ill patients were older,had higher BMI,similar clinical symptoms,and lymphocytes than patients with mild and general type Lower counts,earlier changes in blood gas,higher erythrocyte sedimentation,lower CA and FE,and more significant decreases in CD4 and CD8 counts.The changes of lymphocyte count,blood gas,ESR,CA and FE and T lymphocyte subsets will appear earlier in the week before the disease is aggravated,which has a certain early warning effect on the severity of the disease.