在常规药物治疗基础上联合应用氯吡格雷治疗急性心绞痛的临床效果探究分析

Analysis of clinical effects of combined application of clopidogrel on acute angina pectoris based on conventional drug therapy

目的研究在常规药物治疗基础上联合应用氯吡格雷治疗急性心绞痛的临床效果。方法选取2017年5月—2018年5月医院收治的急性心绞痛患者116例,随机分为对照组和观察组,每组58例。对照组采用常规药物治疗,观察组在常规药物治疗基础上联合应用氯吡格雷。比较两组的治疗效果,以及治疗前后的心绞痛发作次数和持续时间。结果观察组治疗总有效率为96.55%,高于对照组的75.86%,差异有统计学意义(χ^2=8.773,P<0.05)。两组治疗前心绞痛发作次数、持续时间相比,差异无统计学意义(P>0.05);治疗后,观察组心绞痛发作次数(0.38±0.08)次、每次持续时间(2.75±1.03)min,分别少于对照组的(1.47±0.67)次、(5.42±2.25)min,差异有统计学意义(t=4.379、6.262,P<0.05)。结论在急性心绞痛的治疗中,在常规药物治疗基础上联合应用氯吡格雷,能够提高治疗总有效率,减少心绞痛发作次数,缩短每次发作时间,取得了良好的临床效果。

Objective To study the clinical effect of combined clopidogrel treatment of acute angina pectoris based on conventional drug therapy.Methods 116 patients with acute angina pectoris treated in the hospital from May 2017 to May 2018 were randomly divided into a control group and an observation group,with 58 patients in each group.The control group was treated with conventional drugs,and the observation group was given clopidogrel in combination with conventional drugs.The treatment effects of the two groups were compared,and the number and duration of angina pectoris before and after treatment were compared.Results The total effective rate of treatment in the observation group was 96.55%,which was higher than 75.86%in the control group.There was a significant difference(χ^2=8.773,P<0.05).There were no significant differences in the number and duration of angina pectoris before treatment in the two groups(P>0.05);after treatment,the number of angina pectoris in the observation group(0.38±0.08)times and each duration(2.75±1.03)min were respectively(1.47±0.67)times and(5.42±2.25)min less than the control group,there were statistically significant differences(t=4.379,6.262,P<0.05).Conclusion In the treatment of acute angina pectoris,the combined application of clopidogrel based on conventional drug treatment can improve the total effective rate of treatment,reduce the number of angina pectoris attacks,shorten the time of each attack,and achieve good clinical results.