米非司酮预防子宫肌瘤切除术后复发的价值

The Value of Mifepristone in Preventing Recurrence after Hysteromyoma Resection

目的探讨米非司酮在有效预防临床子宫肌瘤患者术后复发中的应用与效果。方法选取该院于2017年4月-2018年6月收治的106例子宫肌瘤患者作为观察对象,随机将患者分成甲乙两组,各53例,两组均接受子宫切除术治疗,甲组术后未接受药物治疗,乙组术后应用米非司酮,观察两组患者术后复发情况。结果乙组患者术后阴道流血时间(9.1±3.7)d、月经恢复时间(31.5±5.4)d均短于甲组(13.6±4.3)d、(70.2±11.4)d,差异有统计学意义(t=5.395、8.332,P<0.05);且乙组患者术后肿瘤复发率(3.77%)低于甲组(24.53%),差异有统计学意义(χ^2=8.582,P<0.05);同时,乙组患者术后血清中P(0.34±0.21)μg/L、E2(120.2±54.4)ng/L与FSH(6.2±2.3)IU/L指标水平均低于甲组(0.62±0.21)μg/L、(192.4±35.3)ng/L、(8.3±3.7)IU/L,差异有统计学意义(t=4.738、7.846、4.463,P<0.05)。结论术后给予子宫肌瘤切除术患者米非司酮应用,可明显降低患者术后复发情况,效果显著。

Objective To explore the application and effect of mifepristone in the effective prevention of postoperative recurrence of patients with clinical uterine fibroids. Methods A total of 106 patients with uterine fibroids who were treated in the hospital from April 2017 to June 2018 were selected as observation objects. The patients were randomly divided into two groups, 53 patients in group A and group B each. Both groups received hysterectomy and group A.After receiving no medication, group B was treated with mifepristone and the recurrence of the patients in the two groups was observed. Results Patients in group B had vaginal bleeding time(9.1 ±3.7)d and menstrual recovery time(70.2±11.4)d, which were shorter than those in group A(13.6±4.3)d and(31.5±5.4)d. The differences were statistically significant(t=5.395, 8.332, P<0.05);and the tumor recurrence rate of patients in group B(3.77%) was lower than that in group A(24.53%), and the difference was statistically significant(χ^2=8.582, P<0.05);meanwhile, patients in group B Serum levels of P(0.34±0.21)μg/g, E2(120.2±54.4)ng/L, and FSH(6.2±2.3)IV/L were lower than those in group A(0.62 ±0.21)μg/L,(192.4 ±35.3)ng/L, and(8.3 ±3.7)IU/L, and the difference was statistically significant(t =4.738, 7.846,4.463, P <0.05). Conclusion Mifepristone application in patients with hysteromyoma resection after surgery can significantly reduce the recurrence of patients with significant effects.