顶复门原虫醛缩酶的生物学功能与应用进展

Advance in Biological Functions and Applications of Aldolase in Apicomplexa

顶复门原虫是一类专一性细胞内寄生原虫,不仅危害畜禽的健康,有些种类还是人兽共患病原,威胁人类的健康。醛缩酶是一类可逆醇醛裂合酶,根据作用机理可分为Ⅰ型与Ⅱ型醛缩酶。研究发现,顶复门原虫存在Ⅰ型醛缩酶,它们主要参与顶复门原虫的能量代谢、虫体黏附及入侵宿主细胞等过程,或可成为抗原虫药物研发的候选靶标。论文主要对顶复门原虫醛缩酶的生物学功能与应用研究现状进行综述,以期为顶复门原虫感染的防控提供参考。

The Apicomplexa are a phylum of intracellular parasites that not only damage the domestic livestock and poultry industries,but some zoonotic parasites also threaten to the health of human.Aldolase promotes reversible cleavage of aldols,which has been classified into typeⅠand typeⅡaldolases according to the mechanism of action.The previous researches revealed that the aldolases in Apicomplexan parasites belonged to typeⅠaldolase.These aldolases involved in the energy metabolism,adhesion and invasion of Apicomplexan parasites.Aldolase is considered as a potential drug target against Apicomplexan parasites.This paper reviewed the biological functions and applications of aldolase in Apicomplexan parasites and provided new ideas for the control of Apicomplexan parasites infection.