血液灌流联合血液透析治疗对尿毒症患者血清β2-MG、PTH水平及预后的治疗效果以及生活质量情况分析

Therapeutic Effect of Blood Perfusion Combined with Hemodialysis on Serum β2-MG,PTH Levels and Prognosis in Uremic Patients and Analysis of Quality of Life

目的探究血液灌流联合血液透析治疗对尿毒症患者血清β2微球蛋白(血清β2-MG)、甲状旁腺激素(PTH)水平及预后的治疗效果以及生活质量情况。方法该研究对象为方便选取该院80例尿毒症患者,研究时间为2018年2月—2019年1月,分为参照组与研究组,每组40例,给予参照组血液透析治疗,给予研究组血液灌流联合血液透析治疗。对比血清β2-MG、PTH水平、治疗效果、症状评分、生活质量、满意度。结果研究组患者治疗后8周血清β2-MG(79.78±22.65)ng/L、PTH水平(9.19±2.96)mg/L均优于参照组血清β2-MG(108.93±29.76)ng/L、PTH水平(17.65±3.29)mg/L,差异有统计学意义(t=5.983、6.394,P<0.05)。研究组患者治疗有效率(95.00%)高于参照组(80.00%),差异有统计学意义(χ2=4.114,P<0.05)。研究组治疗后症状积分(1.08±0.15)分优于参照组(2.04±0.21)分,差异有统计学意义(t=4.986,P<0.05)。研究组治疗后生活质量评分(6.12±0.64)分均优于参照组(5.01±0.35)分,差异有统计学意义(t=4.785,P<0.05)。研究组患者满意度(97.50%)高于参照组(82.50%),差异有统计学意义(χ2=5.000,P<0.05)。结论尿毒症患者实施血液灌流联合血液透析治疗,有效调节血清β2-MG、PTH水平,改善临床症状,提高治疗有效率,提升生活质量,得到满意评价。

Objective To explore the therapeutic effects of hemoperfusion and hemodialysis on serumβ2 microglobulin(serumβ2-MG),parathyroid hormone(PTH)levels,prognosis and quality of life in patients with uremia.Methods The study involved 80 patients with uremia in the hospital.The study period was from February 2018 to January 2019.They were convenient selection divided into the reference group and the research group,with 40 patients in each group.Serum levels of levelβ2-MG,PTH,treatment effect,symptom score,quality of life and satisfaction were compared.Results The serum levels of the study group at 8 weeks after treatment wereβ2-mg(79.78±22.65)ng/L and PTH(9.19±2.96)mg/L,respectively,which were better than those of the control group atβ2-MG(108.93±29.76)ng/L and PTH(17.65±3.29)mg/L,with statistical significance(t=5.983,6.394,P<0.05).The effective rate(95.00%)in the study group was higher than that in the control group(80.00%),with statistical significance(χ2=4.114,P<0.05).After treatment,the symptom score(1.08±0.15)points of the study group was better than that of the control group(2.04±0.21)points,with statistical significance(t=4.986,P<0.05).The quality of life score of the study group after treatment(6.12±0.64)points was better than that of the control group(5.01±0.35)points,with statistical significance(t=4.785,P<0.05).The satisfaction of patients in the study group(97.50%)was higher than that in the control group(82.50%),with statistical significance(χ2=5.000,P<0.05).Conclusion Hemoperfusion combined with dialysis can effectively regulate the level of serumβ2-MG,PTH,improve the clinical symptoms,improve the effective rate of treatment and improve the quality of life in uremic patients.