阿司匹林肠溶片联合硫酸氢氯吡格雷片治疗冠心病心绞痛的疗效分析

Efficacy of Aspirin Enteric-coated Tablets Combined with Clopidogrel Bisulfate Tablets in the Treatment of Coronary Heart Disease and Angina Pectoris

目的探讨冠心病心绞痛采用硫酸氢氯吡格雷片联合阿司匹林肠溶片治疗的效果。方法方便选取2017年6月-2018年6月收治的冠心病心绞痛患者98例,采取数字随机法分为观察组(阿司匹林肠溶片联合硫酸氢氯吡格雷片)和对照组(阿司匹林肠溶片),各49例,对比治疗效果。结果观察组治疗总有效率93.88%、心绞痛发作次数(1.18±0.19)次/d、持续时间(4.25±0.14)min、发作间隔时间(5.15±0.53)d、APTT(40.32±1.32)s均优于对照组75.51%、(3.42±0.48)次/d,(8.23±1.18)min、(3.06±0.16)d、(48.86±1.41)s,对比差异有统计学意义(χ~2=12.704;t=31.742、23.462、26.368、3.789;P<0.05);两组不良反应、PA、PT对比差异无统计学意义(t=0.159、0.789、0.159,P>0.05)。结论阿司匹林肠溶片联合硫酸氢氯吡格雷片治疗冠心病心绞痛效果显著,可有效改善患者心绞痛,提升治疗效果,值得推广。

Objective To observe the effect of treating angina pectoris of coronary heart disease(CHD) with hydrochloropyra tablets combined with aspirin enteric tablets. Methods 98 patients with angina pectoris from June 2017 to June 2018 were convenient selected, and the digital randomization method was used to divide them into the observation group(aspirin enteric tablets combined with hydrogen chloropyglé sulfate tablets) and the control group(aspirin enteric tablets). In each case, 49 cases were compared with the treatment effect. Results The total effective rate of treatment in the observation group was93.88%, the number of angina pectoris attacks(1.18±0.19) times/d, duration(4.25±0.14) min, attack interval(5.15±0.53) d,APTT(40.32±1.32)s were all better than those in the control group by 75.51%,(3.42±0.48) times/d,(8.23±1.18) min,(3.06±0.16)d,(48.86±1.41) s, the different were statistical significance(χ~2=12.704;t=31.742, 23.462, 26.368, 3.789;P<0.05). There was no statistically significant difference in adverse reactions, PA and PT between the two groups(t=0.159,0.789, 0.159, P>0.05). Conclusion Aspirin enteric tablets combined with hydrochloropygrigre tablets are effective in the treatment of angina pectoris in patients with coronary heart disease.