了哥王生物活性及抗肿瘤作用研究进展

Research progress on bioactivity and anti-tumor effects of the Wikstroemia indica

通过查阅及整理国内外有关了哥王的相关文献,对了哥王发挥药理作用的活性部位以及抗肿瘤作用的化学成分进行归纳总结。了哥王中含有木质素类、黄酮类、香豆素类、甾体类、挥发油类、酸、酯、醇以及萜类等化学成分,具有抗菌、抗病毒、细胞毒、抗炎、抑制肿瘤细胞生长等药理活性。文献研究表明,了哥王的抗炎、抗菌及抗病毒成分主要存在于乙酸乙酯部位。此外,大量研究报道了哥王具有显著的抗肿瘤活性,对多种肿瘤细胞有抑制作用,该研究得到了国内外研究者的关注,使该药成为研究热点。建议对了哥王的药理活性物质及抗肿瘤机制等作深一步研究。

By resourcing and sorting the references of Wikstroemia indica at home and abroad,it has been summarized the active parts of the pharmacological action of wikstroemia indicaas and the chemical components of anti-tumor effects,studies found that the wikstroemia indicaas contains lignins,flavonoids,coumarins,steroids,volatile oils,acids,esters,alcohols and anthraquinones,and has the effects of antibacterial,antiviral,cytotoxic,anti-inflammatory,and inhibition of tumor cell growth.The anti-inflammatory,antibacterial and anti-viral components of the Wikstroemia indica are mainly found in the ethyl acetate site.In addition,a large number of studies have reported that the wikstroemia indicaas has been concerned about inhibiting tumor cell growth,and its anti-tumor cell research has gradually become a new research hotspot.It is recommended to conduct a further study on the pharmacologically active substances and anti-tumor mechanisms of the Wikstroemia indica.