小剂量α-干扰素联合维生素A治疗小儿麻疹效果与安全性

Effect and safety of low dose IFN-αcombined with vitamin A in treatment of infantile measles

目的对小儿麻疹应用小剂量干扰素-α(IFN-α)联合维生素A治疗的临床效果进行探析。方法将2017年2月至2018年2月在该院儿科诊治的104例麻疹患儿纳入研究中,采用数字表法随机分成研究组和对照组,各52例;两组均给予积极对症治疗,对照组同时应用维生素A,研究组联用维生素A和小剂量IFN-α治疗,对比分析两组疗效。结果研究组治疗总有效率为96.15%,显著高于对照组的82.69%(P<0.05);研究组患儿退热时间、咳嗽停止时间、腹泻停止时间、肺部啰音消失时间及皮疹消退时间均短于对照组,比较差异有统计学意义(P<0.05);两组患儿用药中均未出现明显不良反应。结论在小儿麻疹治疗中联用小剂量IFN-α、维生素A可有效提升疗效,改善患儿症状,促进康复,且有良好安全性,有着重要临床价值。

【Objective】To explore the clinical effect of low dose interferon alpha(IFN-α)combined with vitamin A in treatment of measles in children.【Methods】Totally 104 cases of measles children in the Pediatrics Department of our hospital from February 2017 to February 2018 were included in the study.They were randomly divided into the study group and the control group using digital table method,with 52 cases in each group.The two groups were all given positive symptomatic treatment,the control group used vitamin A simultaneously,the study group combined vitamin A and small dose IFN-α,and the efficacy of the two groups were compared and analyzed.【Results】The total effective rate of treatment in the study group was 96.15%,which was significantly higher than that of the control group(P<0.05).The time of fever,coughing cessation,cessation of diarrhea,the disappearance time of lung rale and the retreating time of rale in the study group were shorter than those in the control group,and the difference was statistically significant(P<0.05).The two groups did not appear obvious drug adverse reactions.【Conclusion】The combined use of small dose of IFN-αand vitamin in the treatment of measles in children can effectively improve the curative effect,improve the symptoms of the children,promote the rehabilitation,and have good safety.It has important clinical value.