氢溴酸西酞普兰片联合百忧解治疗脑梗死后抑郁患者的疗效研究

Therapeutic effect of citalopram hydrobromide tablets combined with prozac on patients with post-cerebral infarction depression

目的探索氢溴酸西酞普兰片联合百忧解治疗脑梗死后抑郁患者的疗效。方法选取2017年4月至2018年4月在该院接受治疗的168例脑梗死后抑郁患者为研究对象,按照随机数表法随机分为对照组和观察组,对照组应用氢溴酸西酞普兰片治疗,观察组在对照组基础上添加百忧解治疗。采用汉密尔顿抑郁量表(HAMD)、焦虑自评量表(SAS)、抑郁自评量表(SDS)对治疗前后患者焦虑、抑郁情况进行评价,统计患者临床疗效总有效率和不良反应总发生率。结果观察组治疗后HAMD为(12.06±3.18)分,SAS为(32.12±11.05)分,SDS评分为(34.86±10.69)分,分别显著低于对照组治疗后HAMD(24.68±7.82)分,SAS(59.46±21.09)分,SDS(53.20±19.07)分,数据对比差异具有统计学意义(P<0.05)。观察组治疗后总有效率为82.14%,明显高于对照组治疗后总有效率的69.05%,数据对比差异具有统计学意义(P<0.05)。观察组不良反应总发生率为5.95%,显著低于对照组不良反应总发生率的19.05%,数据对比差异具有统计学意义(P<0.05)。结论氢溴酸西酞普兰片联合百忧解治疗方案较单一氢溴酸西酞普兰片治疗脑梗死后抑郁患者疗效更为显著,且脑梗死后抑郁患者抑郁情况得到显著改善,患者治疗过程中不良反应发生较少,安全性较好,适合临床推广应用。

【Objective】To explore the efficacy of citalopram hydrobromide tablets combined with prozac in the treatment of post-cerebral infarction depression.【Methods】Totally 168 patients with post-cerebral infarction depression who were treated in our hospital from April 2017 to April 2018 were enrolled in the study.They were randomly divided into the control group and the observation group according to the random number table method.The control group was treated with citalopram hydrobromide tablets,the observation group added prozac treatment on the basis of the control group.The Hamilton Depression Scale(HAMD),Self-rating Anxiety Scale(SAS),and Self-rating Depression Scale(SDS)were used to evaluate the anxiety and depression of patients before and after treatment.The total effective rate and the total incidence of adverse reactions were statistically analyzed.【Results】The HAMD of the observation group was(12.06±3.18),the SAS was(32.12±11.05),and the SDS score was(34.86±10.69),which was significantly lower than the HAMD after treatment(24.68±7.82),SAS(59.46±21.09),SDS(53.20±19.07)points,the data comparison was statistically significant(P<0.05).The total effective rate after treatment in the observation group was 82.14%,which was significantly higher than the total effective rate after treatment in the control group(69.05%),and the difference between the two groups was statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was 5.95%,which was significantly lower than the total incidence of adverse reactions in the control group(19.05%),and the difference was statistically significant(P<0.05).【Conclusion】The combination of citalopram hydrobromide tablets and prozac treatment is more effective than the single citalopram hydrobromide tablets for the treatment of post-cerebral infarction depression,and the depression in patients with post-cerebral infarction is significantly improved.Less reaction occurs,safety is better,so it is suitable for clinical application.