肾性贫血患者红细胞参数与微炎症状况之间的相关性

Correlation between erythrocyte parameters and microinflammatory status in patients with renal anemia

目的比较肾性贫血患者红细胞参数与健康人的差异,并探讨肾性贫血患者红细胞计数与C反应蛋白之间的相关性。方法收集2017年9月至2018年9月在该院治疗的30例肾性贫血患者作为肾性贫血组,选择同期体检的健康人30例作为对照组,检测两组患者红细胞参数[红细胞(RBC)、血红蛋白(HGB)、平均红细胞体积(MCV)、红细胞比容(HCT)、平均红细胞血红蛋白量(MCH)、红细胞平均血红蛋白浓度(MCHC)、红细胞分布宽度变异系数(RDW-CV)和红细胞分布宽度标准差(RDW-SD)]与炎症指标[C反应蛋白(CRP)、白蛋白(ALB)和白蛋白/球蛋白(A/G)]之间的差异性。结果肾性贫血患者的RBC、HGB、MCV、HCT、MCH和MCHC均低于对照组(P<0.01);肾性贫血患者的CRP和ALB均高于对照组(P<0.01),而A/G低于对照组(P<0.01);肾性贫血患者的RBC与CRP呈负相关。结论肾性贫血患者体内红细胞参数均显著下降,并伴有微炎症状态。

【Objective】To compare the red blood cell parameters between renal anemia patients and healthy people,and to explore the correlation between red blood cell count and C-reactive protein in renal anemia patients.【Methods】Thirty renal anemia patients treated in our hospital from September 2017 to September 2018 were collected as the renal anemia group,and 30 healthy people who underwent physical examination during the same period were selected as the control group.The differences in red blood cell parameters(RBC,HGB,MCV,HCT,MCH,MCHC,RDW-CV and RDW-SD)and inflammatory indicators(CRP,ALB and A/G)between the two groups were detected.【Results】RBC,HGB,MCV,HCT,MCH and MCHC in renal anemia patients were significantly lower than those in the control group(P<0.01).CRP and ALB in renal anemia patients were significantly higher than those in the control group(P<0.01),while A/G was significantly lower than that in the control group(P<0.05).RBC was significantly negatively associated with CRP in patients with renal anemia.【Conclusion】Erythrocyte parameters of renal anemia patients were significantly decreased,which was accompanied by microinflammatory status.