肺炎支原体肺炎患儿血清维生素A、维生素D水平变化及临床意义

Serum Vitamin A,Vitamin D levels in children with Mycoplasma pneumoniae pneumonia

目的分析肺炎支原体肺炎患儿血清维生素A、维生素D水平变化以及临床意义。方法将2017年5月至2019年5月治疗的280例肺炎支原体肺炎患儿纳入观察组,并选择同期入院的240例非支原体肺炎患儿作为对照组,选取同期入院的80例健康体检儿童作为健康组。采用酶联免疫吸附法检测研究对象血清维生素A、维生素D水平。比较三组儿童血清维生素A、维生素D水平差异,同时分析不同血清维生素A、维生素D水平的肺炎支原体肺炎患儿治疗效果差异。结果观察组患儿住院时间、咳嗽消失时间、住院费用、CRP水平均高于对照组(P<0.01)。三组患儿血清维生素A、维生素D水平比较有统计学差异(观察组<对照组<健康组,P<0.01)。观察组患儿维生素A缺乏、维生素D缺乏情况均明显高于对照组、健康组(维生素A:45.71%vs 8.33%vs 0,P<0.01;维生素D:26.79%vs 3.33%vs 0,P<0.01)。观察组出现维生素A、维生素D缺乏患儿的住院时间、咳嗽消失时间、住院费用、CRP水平均高于非缺乏患儿(P<0.01)。结论肺炎支原体肺炎患儿血清维生素A、维生素D水平较低,且维生素A、维生素D缺乏患儿住院时间、咳嗽时间长,住院费用高。因此,临床中促进患者康复,应密切监测患儿血清维生素A、维生素D水平变化。

Objective To investigate the changes and significances of serum vitamin A and vitamin D levels in children with Mycoplasma pneumoniae pneumonia(MPP).Methods A total of 280 MPP children treated from May 2017 to May 2019 were included in observation group,240 children with pneumonia(non-MPP) admitted to hospital in the same period were selected as control group,and 80 healthy children were served as health group.Serum vitamin A and vitamin D levels were measured by ELISA and compared among three groups.The curative effect was analyzed in the treatment of MPP in children with different serum vitamin A,vitamin D levels.Results Compared with control group,the hospital stay,cough duration,hospitalization expenses and C-reactive protein(CRP) level increased significantly in observation group(P<0.01). The serum levels of vitamin A and vitamin D were the lowest in observation group,and they were statistically lower in control group than those in healthy group(P<0.01).The incidences of vitamin A deficiency(45.71% vs 8.33% vs 0) and vitamin D deficiency(26.79% vs 3.33% vs 0) were significantly higher in observation group than those in control group(P<0.01).In observation group,the hospitalization time,cough duration,hospitalization expenses and CRP level in children with vitamin A and vitamin D deficiency significantly increased compared with children without vitamin A and vitamin D deficiency(P<0.01).Conclusions Children with MPP have low vitamin A and vitamin D levels,and children with vitamin deficiency have longer hospitalization time and cough duration and higher hospitalization cost.Therefore,the serum vitamin A and vitamin D levels should closely be monitored to promote the recovery of MPP patients in clinic.