小檗碱对多囊卵巢综合征子宫内膜病变的作用研究进展

Research Progress on the Effect of Berberine on PCOS Endometrial Lesion

总结小檗碱对多囊卵巢综合征(polycystic ovary syndrome,PCOS)子宫内膜增生病变和子宫内膜癌的作用机理,以期为小檗碱进一步的研究和推广提供依据。小檗碱能够通过改善胰岛素抵抗、调血脂、降血糖、抑制卵巢细胞分泌雄激素等,有效防治PCOS子宫内膜增生病变;小檗碱能通过调控COX-2转录、阻断NF-κB信号通路、破坏细胞结构及抑制线粒体氧化等途径抑制子宫内膜癌细胞的增殖和转移。但目前还需要更多严谨的临床观察和实验研究来验证小檗碱治疗子宫内膜病变的作用机理和有效性。

The mechanism of berberine in PCOS intimal hyperplasia and endometrial carcinoma was discussed in order to provide evidence for further study and popularization of berberine. It is considered that berberine can effectively pretreat PCOS intimal hyperplasia by improving insulin resistance, regulating lipid, lowering glucose and inhibiting the secretion of androgens in the ovarian cells. At the same time, berberine can also inhibit the proliferation and metastasis of endometrial cancer cells by regulating COX-2 transcription, blocking NF-kB signaling pathway, destroying cell structure and inhibiting mitochondrial oxidation. However, in general, more rigorous clinical observation and experiments are needed to verify the mechanism and effectiveness of berberine in the treatment of endometrial lesion.