摘要
树状大分子基于其高度支化的结构及可调控性,良好的理化性质、单分散性及生物相容性,近几年已普遍用于构建多种纳米抗肿瘤药物,目前树状大分子已成为抗癌药物的研究热点。本文中,笔者主要对近年来基于树状大分子的纳米抗癌药物,包括化学、基因、放射性、光热、光动力抗癌药物的构建及其抗癌应用进行综述,为构建新型抗肿瘤药物提供参考。
Based on the highly branched structure,well controlled property,excellent physicochemical property,monodispersity and biocompatibility,dendrimer has been widely used to construct various anticancer nanomedicines.At present,dendrimer has been the hot research topic in the field of anticancer drugs.In this review,dendrimer-based anticancer nanomedicine,including the construction and anticancer application of chemical,genetic,radioactive,photothermal,and photodynamic anticancer drugs in recent years are summarized,to provide basis for novel anticancer drug.
作者
朱静怡
杨军星
武明豪
黄和
ZHU Jingyi;YANG Junxing;WU Minghao;HUANG He(School of Pharmaceutical Sciences,Nanjing Tech University,Nanjing 211800,China;National Clinical Research Center for Cancer,Tianjin Medical University Cancer Institute and Hospital,Tianjin 300060,China)
出处
《生物加工过程》
CAS
2020年第3期346-353,共8页
Chinese Journal of Bioprocess Engineering
基金
国家自然科学基金(21807059)
江苏省自然科学基金(BK20180711)
江苏省高等学校自然科学研究面上项目(17KJB350005)。
