急性百草枯农药中毒患者35例预后相关因素分析

Analysis of Relevant Factors of Prognosis in 35 Patients with Acute Paraquat Poisoning

目的:探讨急性百草枯农药中毒患者预后相关因素,以提高急性百草枯农药中毒的急救水平。方法:回顾性分析我院2015年1月-2019年12月间收治的35例口服百草枯中毒患者的临床资料,比较生存组(n=17)及死亡组(n=18)间患者服毒剂量、外周血白细胞水平、血清肌酐值、中毒至初诊时间、中毒至洗胃时间、中毒至开始血液净化时间、血液净化治疗方式等因素。结果:两组间服毒剂量、白细胞水平、肌酐的差异有统计学意义(P<0.05),而中毒至初诊时间、中毒至洗胃时间、中毒至血液净化时间以及不同血液净化方式的组间比较无明显统计学差异(P>0.05)。结论:在目前医疗背景较成熟的城市环境下,影响急性百草枯农药中毒患者预后的最主要因素为服毒剂量、外周血白细胞计数及血清肌酐值,其增高可提示患者预后不良。

Objective:To explore the predictability and influence of related factors on the prognosis of patients with acute paraquat(PQ)poisoning,and to improve the first aid level of acute PQ pesticide poisoning.Methods:The clinical data of 35 patients with oral PQ poisoning treated in the hospital from Jan 2015 to Dec 2019 were retrospectively ana-lyzed.The cases were divided into the survival group(n=17)and the death group(n=18).We analyzed whether there were differences in the taking poison quantity,peripheral white blood cells(WBC)count,creatinine(Cr),the time from poisoning to first visit,the time from poisoning to gastric lavage,the time from poisoning to the beginning of blood purifi-cation therapy and the mode of blood purification treatment between the survival group and the death group.Results:There were significant differences in the taking poison quantity,WBC and Cr between the two groups(P<0.05).There was no significant difference in the time from poisoning to first visit,the time from poisoning to gastric lavage,from poi-soning to blood purification and different blood purification methods(P>0.05).Conclusion:In the urban environment with mature medical background,the most important factor affecting the prognosis of patients with acute PQ pesticide poisoning is the taking poison quantity.The increase of WBC and Cr may have a high predictive value for poor ending.