小儿卵巢恶性肿瘤的生育保护

Fertility preservation of malignant ovarian tumors in children and adolescents

随着综合治疗模式的发展及进步,儿童和青少年卵巢肿瘤患者生存时间延长,人们对其生活质量的关注日益增加,治疗后生育力的下降成为一个重要问题。几乎所有研究表明肿瘤治疗对于生育力具有不同程度的损伤,主要是性腺器官的丧失、卵巢早衰等导致怀孕率下降。目前,国内外的医疗中心在小儿卵巢肿瘤的管理方面,都提及生育保护的原则,开发不同的术前诊断及评估系统、探索综合治疗模式,尽可能减少卵巢组织损失或功能损伤。同时,生育保存技术也在不断进步发展中,给不可避免受到性腺损伤的患儿带来了生育希望。本文旨在综述近年国内外小儿卵巢恶性肿瘤治疗中的生育保护现状。

With the development of comprehensive treatment modes,children and adolescents with ovarian tumor have a longer survival time and people pay more and more attention to their quality-of-life.A decline of fertility after treatment has become an important issue.Almost all studies have demonstrated that tumor therapies have varying degrees of fertility injury.A loss of gonad organs and premature ovarian failure result in a lower pregnancy rate.While managing pediatric ovarian tumors,medical centers all adhere to the principle of reproductive protection,formulate different preoperative diagnosis and evaluation systems and explore comprehensive treatment modes to avoid ovarian tissue loss or functional impairment.At the same time,evolving technology of fertility preservation is also bringing fertility hopes to children with potential injuries of gonad organs.Here current status and recent advances of fertility protection in the treatment of malignant ovarian tumors in children are reviewed.