肺炎链球菌脑膜炎病原学诊断进展

Advances in the pathogenic diagnosis of pneumococcal meningitis

儿童细菌性脑膜炎感染可引起严重的并发症和后遗症,肺炎链球菌是该病重要的病原体,早期快速明确感染的病原体,对于精准治疗、降低其病死率和减少后遗症均有重要意义。近年来,分子生物学方法的快速进展使临床病原的诊断模式发生了巨大改变。现主要从肺炎链球菌脑膜炎病原体诊断进展方面进行阐述,以更加系统地了解新兴技术的发展在肺炎链球菌脑膜炎精确诊断中的作用。

Bacterial meningitis infections can cause serious complications and sequelae in children.Streptococcus pneumoniae is a major pathogen of the disease.Early and rapid identification of the pathogen of infection is of great significance for precise treatment,as well as mortality and reduction of sequelae.In recent years,the rapid progress of molecular biology methods has enormously changed the clinical pathogen diagnosis pattern.In this article,the progress in the pathogenic diagnosis of pneumococcal meningitis was reviewed,in order to acquire a better and systematic understanding of the role that emerging technologies play in the accurate diagnosis of pneumococcal meningitis.