同型半胱氨酸对缺血性脑卒中的影响

Effect of homocysteine on ischemic stroke

同型半胱氨酸是引起缺血性脑卒中的重要风险因子,并且参与缺血后引起的的一系列损伤,其机制包括氧化应激、血管内皮损伤、炎症反应、表观遗传学改变等。同时,同型半胱氨酸也对卒中的复发、血管性痴呆、脑出血、卒中后肾功能不全等卒中后相关疾病有着广泛的影响。本文将分别从同型半胱氨酸参与卒中分子神经功能损伤机制以及卒中预后两个方面阐述同型半胱氨酸在脑缺血中的作用。

Homocysteine is one of the important risk factors in ischemic stroke involved a series of injuries. The mechanisms including oxidative stress, vascular endothelial injury, inflammatory response, epigenetic changes, etc. High homocysteine has a certain reference value for the prognosis of stroke, involving recurrence of ischemic stroke, occurrence of vascular dementia, cerebral microbleeds, and renal insufficiency after stroke. It is helpful for the prevention and treatment of ischemic stroke to elucidate the link between homocysteine and brain cell damage. This article explain the role of homocysteine in cerebral ischemia including the risk factors of ischemic stroke, neurological impairment and prognosis.