图像视觉诱发电位自律空间频率刺激疗法治疗儿童弱视的疗效

A controlled clinical study on the effect of PVEP-CD comprehensive therapy for children amblyopia

目的:比较图像视觉诱发电位自律空间频率刺激疗法(PVEP-CD综合疗法)与传统疗法治疗儿童弱视的临床效果,评价PVEP-CD综合疗法治疗儿童弱视的疗效。方法:收集2018-04/2019-01于我院确诊的弱视儿童38例54眼,随机分为传统综合疗法组(19例27眼,运用屈光矫正+遮盖/压抑+精细目力训练治疗)和PVEP-CD综合疗法组(19例27眼,运用屈光矫正+遮盖/压抑+PVEP-CD治疗)。分别于治疗前和治疗6mo后进行最佳矫正视力(BCVA)和近立体视锐度检测,评估临床疗效。结果:治疗6mo后,两组患儿弱视眼BCVA(有效率均≥85%)均明显改善,且PVEP-CD综合疗法组弱视眼BCVA提高行数[3(2,3)行]、双眼近立体视锐度改善有效率(89%)及提高等级[2(1,4)级]均高于传统综合疗法组(均P<0.05);≥6周岁患儿中,PVEP-CD综合疗法组弱视眼BCVA提高行数显著高于传统综合疗法组(P=0.018);轻度弱视患儿中,PVEP-CD综合疗法组近立体视锐度改善有效率(P=0.048)及提高等级(P=0.029)均显著优于传统综合疗法组;中度弱视患儿中,PVEP-CD综合疗法组弱视眼BCVA提高行数显著高于传统综合疗法组(P=0.003)。结论:PVEP-CD综合疗法与传统疗法均可有效提高BCVA,临床疗效显著;与传统综合疗法相比,PVEP-CD综合疗法能较大幅度提高BCVA和近立体视锐度等级,更有效地促进弱视儿童双眼视功能恢复。

·AIM:To evaluate the therapeutic effect of the PVEP-CD comprehensive therapy[a multimedia visual training system uses the individualized PVEP(pattern visual evoked potential)sensitive spatial frequency parameters]in children with amblyopia by comparing the differences in visual acuity and stereo acuity enhancement between the PVEP-CD comprehensive therapy and traditional therapy.·METHODS:A total of 38 children(54 eyes)with amblyopia who were treated in our hospital from April 2018 to January 2019 were randomly divided into two groups.Traditional therapy group(19 cases,27 eyes;therapeutic methods contain refractive correction,patching/optical or drug suppress and precision eyesight training);PVEP-CD comprehensive therapy group(19 cases,27 eyes;therapeutic methods contain refractive correction,patching/optical or drug suppress and a multimedia visual training using the individualized P-VEP sensitive spatial frequency parameters).To study the clinic therapeutic effect,the best distance corrected visual acuity(BCVA)and near stereo acuity were measured at the enrollment visit and the final visit after 6mo treatment.·RESULTS:After 6mo treatment,both groups had an apparent BCVA improvement(both therapy effective rate≥85%).PVEP-CD comprehensive therapy group were significantly better than traditional therapy group in BCVA lines improvement[3(2,3)lines],near stereo acuity therapy effective rate(89%)and near stereo acuity level improvement[2(1,4)levels](all P<0.05).In amblyopic children older than 6y,PVEP-CD comprehensive therapy group showed a significantly greater BCVA lines improvement(P=0.018).In mild amblyopia cases,PVEP-CD comprehensive therapy group showed a significantly better clinical efficacy in near stereo acuity(P=0.048)and greater improvement in near stereo acuity level(P=0.029).In moderate amblyopia cases,the BCVA lines improvement(P=0.003)was significantly greater in PVEP-CD comprehensive therapy group.·CONCLUSION:Both PVEP-CD comprehensive and traditional therapy can improve the BCVA in children with amblyopia and have a good clinical efficacy.Furthermore,the PVEP-CD comprehensive therapy could improve the BCVA and near stereo acuity level more obviously and help amblyopic children get a better binocular vision.