肠道微生态与消化系统健康和疾病

Intestinal Microecology in Digestive System Health and Diseases

胃肠道中含有广泛多样、宿主特异性的微生物群,它们不仅适应了胃肠道中独特而多样的环境,而且能对外界各种变异原迅速作出反应,通过一系列生化信号与宿主相互作用,协调营养物质交换,调控免疫功能。宿主与微生物之间的相互作用建立在内环境稳态的基础之上,肠道菌群失调可参与或促进疾病的发生、发展。本文从微生态学角度研究肠道菌群与人类宿主的关系,对近年来发现的肠道微生态与消化系统疾病的关系进行总结。

Gastrointestinal tract contains a wide variety of host-specific microbial communities that not only adapt to the unique and diverse environment in the stomach and intestine,but also respond quickly to all kinds of variants from outside of the body.A series of biochemical signals are occurred for interacting with the host to coordinate the exchange of nutrients and regulate the immune function.The interaction between host and microorganisms is based on homeostasis;dysbiosis of intestinal microbiota contributes to the initiation and development of diseases.The relationship between microbes and host from the perspective of microecology,and the relationship between intestinal microecology and digestive system diseases were summarized in this article.