血清肌钙蛋白联合肌红蛋白检测心肌梗死患者的应用效果

Application effect of combined serum troponin and myoglobin in patients with myocardial infarction

目的探讨血清肌钙蛋白联合肌红蛋白检测心肌梗死患者的应用效果。方法选取2018年8月至2019年8月本院收治的心肌梗死患者3000例,分析心肌梗死患者不同时间段血清肌钙蛋白、肌红蛋白水平及应用效果。结果心肌梗死患者胸痛发作后0~4 h、4~8 h、8~12 h、12~24 h血清肌钙蛋白水平逐渐升高(P<0.05),胸痛发作后0~4 h血清肌钙蛋白水平显著低于3 d(P<0.05),4~8 h与3 d血清肌钙蛋白水平比较差异无统计学意义,8~12 h、12~24 h血清肌钙蛋白水平均显著高于3 d(P<0.05);胸痛发作后0~4 h、4~8 h、8~12 h血清肌红蛋白水平逐渐升高(P<0.05),8~12 h、12~24 h、3 d血清肌红蛋白水平逐渐降低(P<0.05)。肌钙蛋白检测的敏感度、阴性预测值均显著低于肌红蛋白(P<0.05),特异度、准确度、阳性预测值均显著高于肌红蛋白(P<0.05)。结论血清肌钙蛋白与肌红蛋白联合检测心肌梗死患者的应用效果好。

Objective To explore the effect of combined serum troponin and myoglobin detection in patients with myocardial infarction.Methods 3000 cases of patients with myocardial infarction in our hospital from August 2018 to August 2019 were randomly selected.The serum myocardium calcitonin and myoglobin levels in different time periods of the myocardial infarction group,application effects were analyzed.Results The serum troponin levels in patients with myocardial infarction increased gradually at 0-4 h,4-8 h,8-12 h and 12-24 h after onset of chest pain(P<0.05).Serum troponin levels at 0-4 h after onset of chest pain were significantly lower than at 3 d(P<0.05).There was no significant difference between serum troponin levels at 4-8 h and 3 d.Serum troponin levels at 8-12 h and 12-24 h were significant higher than 3 d.The level of serum myoglobin increased gradually at 0-4 h,4-8 h and 8-12 h after chest pain attack(P<0.05),and decreased gradually at 8-12 h,12-24 h and 3 d(P<0.05).The specificity,accuracy and positive predictive value of myoglobin were significantly higher than myoglobin(P<0.05).Conclusion The application effect of combined serum troponin and myoglobin of patients with myocardial infarction is good.